155694-70-5

Upstream product

• 100-47-0 benzonitrile 
• 60198-12-1 N,N-dimethyl-2,4-dimethylbenzamide 
• 21900-42-5 2,4-dimethylbenzoyl chloride 
• 64-17-5 ethanol 
• 1260150-32-0 4-methyl-2-(phenylethynyl)benzonitrile 
• 611-01-8 2,4-dimethyl-benzoic acid 
• 42872-73-1 4-methyl-2-bromobenzonitrile 
• 98-86-2 acetophenone 
• 131002-03-4 4-methyl-2- bromobenzamide 
• 155694-82-9 ethyl 2-bromo-4-methylbenzoate 
• 100-42-5 styrene 
• 68395-72-2 N-phenylselenenyl succinimide 
• 54818-95-0 N,N-diethyl-2,4-dimethyl-benzamide 

Downstream Products

• 1352287-20-7 2,6-dimethyl-1-oxo-3-phenyl-1,2-dihydro-isoquinoline-4-carbaldehyde 
• 1352287-32-1 4-hydroxymethyl-2,6-dimethyl-3-phenyl-2H-isoquinolin-1-one 
• 1352287-66-1 4-ethoxymethyl-2,6-dimethyl-3-phenyl-2H-isoquinolin-1-one 
• 1352287-68-3 4-isobutoxymethyl-2,6-dimethyl-3-phenyl-2H-isoquinolin-1-one 
• 1352287-09-2 2,6-dimethyl-3-phenyl-2H-isoquinolin-1-one 
• 220631-01-6 1-chloro-6-methyl-3-phenylisoquinoline 

Relevant academic research and scientific papers

A different quinolinone and its derivatives

The invention belongs to the technical field of pharmaceutical and chemical intermediates and related chemicals and relates to a preparation method of isoquinolone and derivatives thereof. The isoquinolone and derivatives thereof are important biologically active molecules, skeletal structures frequently appear in natural molecules and drug molecules, and have better therapeutic effect on hypertension, cancer and anxiety disorders and important applications in the fields of organic synthesis and pharmaceutical chemistry. The method is short in synthesis route, mild in conditions and simple in operation and is expected to achieve industrial production and has the advantages of short synthetic route, mild conditions, simple operation and high yield and the like. The isoquinolone and derivatives thereof have greater application value and social and economic benefits.

Isoquinolone synthesis through SNAr reaction of 2-halobenzonitriles with ketones followed by cyclization

An efficient method for the synthesis of isoquinolones through base KOtBu-promoted SNAr reaction of 2-halobenzonitriles with ketones followed by Lewis acid Cu(OAc)2-catalyzed cyclization is described. Isoquinolone derivati

Synthesis of functionalized isoquinolin-1(2H)-ones by copper-catalyzed α-arylation of ketones with 2-halobenzamides

Copper is key: A concise route to isoquinolin-1(2H)-ones from simple and readily available starting materials is provided by an efficient copper-catalyzed annulation of ketones with 2-halobenzamides. The method is applicable to a wide range of ketones con

Synthesis of 12-oxobenzo[c]phenanthridinones and 4-substituted 3-arylisoquinolones via Vilsmeier-Haack reaction

Vilsmeier-Haack reaction on 3-arylisoquinolones resulted in versatile 4-formylated 3-arylisoquinolones that were further derivatized into 12-oxobenzo[c]phenanthridinones, 4-alkoxymethyl-3-arylisoquinolones, 3-aryl-4-phenoxymethylisoquinolones, 4-aminometh

Platinum(II)-catalyzed intramolecular cyclization of alkynylbenzonitriles: Synthesis of 1-alkoxyisoquinolines and isoquinolones

A facile synthesis of a series of 1-alkoxyisoquinolines and (2H)-isoquinolones by an intramolecular 6-endo-dig cyclization of ortho-alkynylbenzonitriles in the presence of a catalytic amount of hydrido(dimethylphosphinous acid-κP)[hydrogen bis(dimethylphosphinito- κP)]platinum(II) in various alcohols at 65-90 °C is described for the first time.

Synthesis and comparative molecular field analysis (CoMFA) of antitumor 3-arylisoquinoline derivatives

In this study a series of 3-arylisoquinoline derivatives were synthesized and cytotoxicity against human melanoma tumor cell evaluated, and a three dimensional quantitative structure-activity relationship was investigated using the comparative molecular field analysis (CoMFA). The results suggested that the electrostatic, steric and hydrophobic factors of 3-arylisoquinolines were strongly correlated with the antitumor activity. Considerable predictive ability (cross-validated r2 as high as 0.721) was obtained through CoMFA. Copyright (C) 1998 Elsevier Science Ltd.

Synthesis and biological evaluation of 3-arylisoquinolines as antitumor agents

To investigate the structure-activity relationship of 7,8-dimethoxy-2-methyl-3-(4,5-methylenedioxy-2-vinylphenyl)isoquinolin-1(2H) -one 2, diverse substituted 3-arylisoquinolines were synthesized and tested in vitro antitumor activity against five human tumor cell lines. The results showed a broad antitumor spectrum for a series of 3-arylisoquinolines.

Synthesis of Isocoumarin, 1-Isoquinolone and 4(1H)-Quinolone Derivatives via Seleno-intermediates

The reaction of 2-styrylbenzoic acid 2 with N-phenylselenosuccinimide (N-PPS) affords 3-phenyl-iso-coumarin derivatives 3 and 3,4-dihydro-3-phenyl-4-(phenylseleno)isocoumarins 4 via selenolactonization.The reaction of 2-styrylbenzamides 5 and 1-(2-aminoph