60214-04-2Relevant academic research and scientific papers
One-Pot Synthesis of Decahydropyrene via Tandem C-H Activation/Intramolecular Diels-Alder/1,3-Dipolar Cycloaddition
Lin, Hui,Dong, Lin
, p. 5524 - 5527 (2016)
A novel decahydropyrene synthesis has been successfully developed involving a tandem rhodium-catalyzed C-H activation/intramolecular Diels-Alder reaction/1,3-dipolar cycloaddition cascade process by using diazole as a traceless directing group. The advantage of this one-pot strategy is a quite simple, efficient, highly stereoselective, and unique product structure.
SUBSTITUTED PYRIDAZINONE FOR USE IN THE TREATMENT OF NEUROMUSCULAR DISEASES
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Paragraph 0231; 0232, (2021/11/20)
Substituted pyridazinone compounds, conjugates, and pharmaceutical compositions for use in the treatment of neuromuscular diseases, such as Duchenne Muscular Dystrophy (DMD), are disclosed herein. The disclosed compounds are useful, among other things, in the treating of DMD and modulating inflammatory inhibitors IL-1, IL-6 or TNF-α.
PYRIDAZINONE COMPOUNDS AND USES THEREOF
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Paragraph 0228, (2020/06/01)
Substituted pyridazinone compounds, conjugates, and pharmaceutical compositions for use in the treatment of neuromuscular diseases, such as Duchenne Muscular Dystrophy (DMD), are disclosed herein. The disclosed compounds are useful, among other things, in the treating of DMD and modulating inflammatory inhibitors IL-1, IL-6 or TNF-α.
FIVE-MEMBERED HETEROCYCLIC AMIDES WNT PATHWAY INHIBITOR
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Paragraph 0186-0188, (2018/10/19)
The present invention discloses a five-membered heterocyclic amide WNT pathway inhibitor, which belongs to a compound that regulates the activity of a Wnt signaling pathway, and provides a method for preparing such a compound, and the use of such a compound in preparing a medicament that antagonizes the Wnt signaling pathway. The five-membered heterocyclic amide WNT pathway inhibitor provided by the invention has a remarkable anti-tumor activity based on a target-based rational drug design of, and can be used for the development of a new generation of Wnt pathway inhibitors, and has a great clinical application value and considerable market potential.
Intramolecular cycloadditions of photogenerated azaxylylenes with oxadiazoles provide direct access to versatile polyheterocyclic ketopiperazines containing a spiro-oxirane moiety
Kumar, N. N. Bhuvan,Kuznetsov, Dmitry M.,Kutateladze, Andrei G.
supporting information, p. 438 - 441 (2015/03/03)
Photogenerated azaxylylenes undergo intramolecular cycloadditions to 1,3,4-oxadiazole pendants, which are accompanied by concomitant release of dinitrogen, yielding functionalized ketopiperazinoquinolinols containing an oxirane moiety fused to the quinolinole moiety while spiro-connected to diketopiperazine. These primary photoproducts are reactive versatile intermediates which can be further derivatized under nucleophilic SN1- or SN2-like ring opening of the oxirane moiety. The oxidized quinolinones undergo new rearrangements under the conditions of the Schmidt reaction, leading to unprecedented triazacanoindolinones.
Synthesis, enzyme kinetics and computational evaluation of N-(β-d-glucopyranosyl) oxadiazolecarboxamides as glycogen phosphorylase inhibitors
Polyak, Maria,Varga, Gergely,Szilagyi, Bence,Juhasz, Laszlo,Docsa, Tibor,Gergely, Pal,Begum, Jaida,Hayes, Joseph M.,Somsak, Laszlo
, p. 5738 - 5747 (2013/09/12)
All possible isomers of N-β-d-glucopyranosyl aryl-substituted oxadiazolecarboxamides were synthesised. O-Peracetylated N-cyanocarbonyl-β- d-glucopyranosylamine was transformed into the corresponding N-glucosyl tetrazole-5-carboxamide, which upon acylation
Preparation of 1,3,4-Oxadiazol-2-carboxylic Acid Derivatives
Dost, J.,Heschel, M.,Stein, J.
, p. 109 - 116 (2007/10/02)
The synthesis of 5-substituted-1,3,4-oxadiazol-2-carboxylic acid derivatives 3a-g and 4a-g by cyclodehydratation of diacylhydrazines 1a-g and 2a-g are described.Further derivatives 6 to 9 are obtained from 1,3,4-oxadiazol-2-carboxethyl esters 3.
