60231-37-0Relevant academic research and scientific papers
Catalytic Enantioselective Methylene C(sp3)-H Hydroxylation Using a Chiral Manganese Complex/Carboxylic Acid System
Sun, Qiangsheng,Sun, Wei
, p. 9529 - 9533 (2021/01/09)
Achieving direct C-H hydroxylation in a highly diastereo- and enantioselective manner is still a challenging goal. This reaction is mainly hindered by the potential for overoxidation of the generated alcohols as well as low stereoselectivity. Herein, we present an enantioselective benzylic C-H hydroxylation catalyzed by a manganese complex, H2O2, and a carboxylic acid in 2,2,2-trifluoroethanol. The benzylic alcohols were successfully furnished in excellent diastereoselectivities (up to >95:5) and enantioselectivities (up to 95% ee). As a highlight of this work, high diastereoselectivity of C-H hydroxylation could be achieved by tuning the amount of carboxylic acid additive.
Synthesis of Diastereoisomeric 2-Benzyl-1,2-diphenylindans
Alesso, Elba N.,Bianchi, Daniel E.,Iglesias, Graciela Y. Moltrasio,Sierra, Manuel Gonzalez,Aguirre, Jose M.
, p. 1237 - 1248 (2007/10/02)
The diastereomeric 2-benzyl-1,2-diphenylindan-1-ols were prepared and subjected to deoxygenation reactions under a variety of conditions to obtain 2-benzyl-1,2-diphenylindan.The stereochemistry of these compounds has been characterized on the basis of che
