33982-86-4Relevant academic research and scientific papers
Catalytic Enantioselective Methylene C(sp3)-H Hydroxylation Using a Chiral Manganese Complex/Carboxylic Acid System
Sun, Qiangsheng,Sun, Wei
, p. 9529 - 9533 (2020)
Achieving direct C-H hydroxylation in a highly diastereo- and enantioselective manner is still a challenging goal. This reaction is mainly hindered by the potential for overoxidation of the generated alcohols as well as low stereoselectivity. Herein, we present an enantioselective benzylic C-H hydroxylation catalyzed by a manganese complex, H2O2, and a carboxylic acid in 2,2,2-trifluoroethanol. The benzylic alcohols were successfully furnished in excellent diastereoselectivities (up to >95:5) and enantioselectivities (up to 95% ee). As a highlight of this work, high diastereoselectivity of C-H hydroxylation could be achieved by tuning the amount of carboxylic acid additive.
Alkyl-aryl ketone synthesis via nickel-catalyzed reductive coupling of alkyl halides with aryl acids and anhydrides
Jia, Xiao,Zhang, Xinghua,Qian, Qun,Gong, Hegui
supporting information, p. 10302 - 10305 (2015/06/25)
The present work disclosed a considerably improved method for the construction of alkyl-aryl ketones by the direct coupling of unactivated alkyl bromides with 1.5 equiv. of acids. In addition, the synthesis of aroyl C-glycosides was first achieved by the
Mild ketone formation via Ni-catalyzed reductive coupling of unactivated alkyl halides with acid anhydrides
Yin, Hongyu,Zhao, Chenglong,You, Hengzhi,Lin, Kunhua,Gong, Hegui
supporting information; experimental part, p. 7034 - 7036 (2012/08/14)
Ni-catalyzed ketone formation through mild reductive coupling of a diverse set of unactivated alkyl bromides and iodides with particularly aryl acid anhydrides was successfully developed using zinc as the terminal reductant. These conditions also allow direct coupling of alkyl iodides with aryl acids in the presence of Boc2O and MgCl2. The Royal Society of Chemistry 2012.
Ketone formation via mild Nickel-catalyzed reductive coupling of alkyl halides with aryl acid chlorides
Wu, Fan,Lu, Wenbin,Qian, Qun,Ren, Qinghua,Gong, Hegui
supporting information; experimental part, p. 3044 - 3047 (2012/08/07)
The present work highlights unprecedented Ni-catalyzed reductive coupling of unactivated alkyl iodides with aryl acid chlorides to efficiently generate alkyl aryl ketones under mild conditions.
