6025-68-9

Usage

Uses

Used in Pharmaceutical Industry:
Pyrrolo[1,2-a]quinoxalin-4(5H)-one is used as a potential therapeutic agent for its anti-inflammatory and anticancer properties. It has shown promising results in inhibiting the growth of cancer cells, making it a valuable candidate for the development of novel cancer treatments.
Used in Biomedical Research:
PQX-1 is used as a fluorescent probe for detecting biomolecules. Its unique structural properties allow it to be utilized in various research applications, including the study of molecular interactions and the development of new diagnostic tools.
Used in Organic Synthesis:
Pyrrolo[1,2-a]quinoxalin-4(5H)-one serves as a potential precursor in the synthesis of pharmaceuticals and other organic compounds. Its versatile chemical structure makes it a valuable building block for the development of new drugs and organic materials.

Upstream product

• 125187-92-0 N-phenylpyrrole 
• 3173-56-6 benzyl isothiocyanate 
• 10333-68-3 1-(2-carboxyphenyl)pyrrole 
• 541-41-3 chloroformic acid ethyl ester 
• 1193-62-0 methyl Pyrrole-2-carboxylate 
• 615-43-0 2-iodophenylamine 
• 5427-82-7 1H-pyrrole-2-carbonyl chloride 
• 1315282-52-0 N-(2-bromo-4-chlorophenyl)-1H-pyrrole-2-carboxamide 
• 634-97-9 pyrrole-2-carboxyl acid 

Downstream Products

• 1380392-05-1 5-(3-(4-(4-chlorophenyl)piperidin-1-yl)propyl)pyrrolo[1,2-a]quinoxalin-4(5H)-one 
• 3389-01-3 4-phenylpyrrolo[1,2-a]quinoxaline 

Relevant academic research and scientific papers

Synthesis of pyrrole and indole quinoxalinone and oxazinone derivatives by intramolecular copper-catalyzed reactions

Intramolecular N-arylation of pyrrole and indole carboxamides and carboxylates linked with a pendant haloarene by Cu-catalyzed reactions to synthesize pyrrole and indole quinoxalinone and oxazinone derivatives is reported. The ring closure reactions were carried out by conventional heating and MW irradiation. The use of conventional heating affords moderate to good yields of the quinoxalinone and oxazinone derivatives (34-72%), while by using MW heating the best results are obtained (41-99%). The Royal Society of Chemistry 2011.

A one-pot coupling/hydrolysis/condensation process to pyrrolo[1,2-a] quinoxaline

(Chemical Equation Presented) CuI/L-proline-catalyzed coupling of 2-halotrifluoroacetanilides with pyrrole-2-carboxylate esters in DMSO at 80-90 °C followed by in situ hydrolysis at 60°C afforded pyrrolo[1,2-a] quinoxalines. Indole-2-carboxylate esters underwent the same process smoothly to provide the corresponding tetracyclic products.

Tricyclic pyrrolopyrazine 5-HT3 -active compounds

The present invention relates to a compound selected from these of formula (I): STR1 in which A and R1 are as defined in the description, and medicinal product containing the same which is useful for treating a disorder linked to the 5-HT3 receptors.

New methodology for the preparation of pyrrole and indole derivatives via iminophosphoranes:synthesis of pyrrolo[1,2-a]quinoxalines, indolo[3,2-c]quinolines and indolo[1,2-c]quinazolines

The aza-Wittig reaction of iminophosphorane N-[o-(triphenylphosphoranylidene)amino]-phenyl pyrrole 4 with heterocumulenes leads to functionalized pyrrolo[1,2-a]quinoxalines. Iminophosphorane 19, derived from 2-(o-amino)phenyl indole, reacts under mild con