10333-68-3

Basic information

• Product Name: 1-(2-CARBOXYPHENYL)PYRROLE
• Synonyms: 1-(2-CARBOXYPHENYL)PYRROLE;2-(1H-PYRROL-1-YL)BENZOIC ACID;2-PYRROL-1-YL-BENZOIC ACID;IFLAB-BB F1924-0003;BUTTPARK 75\04-14;2-(1-Pyrrolyl)benzoicacid;2-(1-PYRROLO)BENZOIC ACID;1-(2-Carboxyphenyl)-1H-pyrrole
• CAS NO: 10333-68-3
• Molecular Formula: C₁₁H₉NO₂
• Molecular Weight: 187.19
• Product Categories: Carboxylic Acids;Phenyls & Phenyl-Het;Carboxylic Acids;Phenyls & Phenyl-Het
• Mol File: 10333-68-3.mol
• Article Data: 7

Chemical Properties

• Melting Point: 101 °C
• Boiling Point: 360 °C at 760 mmHg
• Flash Point: 171.5 °C
• Appearance: /
• Density: 1.18 g/cm³
• Vapor Pressure: 8.26E-06mmHg at 25°C
• Refractive Index: 1.596
• PKA: 2.95±0.36(Predicted)
• BRN: 1343920
• CAS DataBase Reference: 1-(2-CARBOXYPHENYL)PYRROLE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-CARBOXYPHENYL)PYRROLE(10333-68-3)
• EPA Substance Registry System: 1-(2-CARBOXYPHENYL)PYRROLE(10333-68-3)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• Hazardous Substances Data: 10333-68-3(Hazardous Substances Data)

Usage

General Description

1-(2-Carboxyphenyl)pyrrole is a chemical compound, which belongs to the pyrrole family. Pyrroles are a class of organic compounds that consist of a five-membered ring with a nitrogen atom. They are aromatic in nature due to delocalization of two pi electrons in the ring. The presence of a carboxylic acid at the 2-position of the phenyl ring in the 1-(2-carboxyphenyl)pyrrole molecule means that this compound has both aromatic and acidic properties. This chemical is used in research and development settings, and information about its properties, such as molecular weight, density, appearance, and melting and boiling points, can be obtained from database resources dedicated to chemistry and biochemistry. However, there is minimal literature available on its specific applications in medical, industrial or other fields.

InChI:InChI=1/C11H9NO2/c13-11(14)9-5-1-2-6-10(9)12-7-3-4-8-12/h1-8H,(H,13,14)

Upstream product

• 696-59-3 cis,trans-2,5-dimethoxytetrahydrofuran 
• 118-92-3 anthranilic acid 
• 134-20-3 2-carbomethoxyaniline 
• 10333-67-2 methyl 2-(1H-pyrrol-1-yl)benzoate 
• 635-90-5 1-phenylpyrrole 
• 124-38-9 carbon dioxide 

Downstream Products

• 1400797-60-5 C₁₈H₁₆N₂O 
• 279256-35-8 tert-butyl-2(R)-[(3,4-methylendioxybenzyl)-(2,6-dimethyl-4-methoxybenzenesulfonyl)amino]-3-[(2-pyrrol-1-yl)phenylcarbonylamino]-propionate 
• 610794-06-4 N-indan-2-yl-N-(3-methyl-benzyl)-2-pyrrol-1-yl-benzamide 
• 1078711-94-0 N-{(3-exo)-8-[(6-fluoro-2-naphthyl)methyl]-8-azabicyclo[3.2.1]oct-3-yl}-2-(1H-pyrrol-1-yl)benzamide 
• 6025-68-9 pyrrolo<1,2-a>quinoxalin-4(5H)-one 
• 133662-32-5 2-(1-pyrrolyl)diazoacetophenone 
• 55540-39-1 acide 2-(1-pyrrolyl)phenyl acetique 
• 140119-63-7 9-(4-methylcyclohexylamino)-9H-pyrrolo<1,2-a>indole 
• 140119-48-8 N-(α-methylbenzyl)-9H-pyrrolo<1,2-a>indol-9-imine 
• 140119-49-9 N-(4-methylcyclohexyl)-9H-pyrrolo<1,2-a>indol-9-imine 
• 140119-41-1 N-(2-(1-pyrrolyl)benzoyl)morpholine 
• 101125-93-3 2-(9H-Pyrrolo[1,2-a]indol-9-ylamino)-ethanol 
• 101125-88-6 2-[Pyrrolo[1,2-a]indol-(9Z)-ylideneamino]-ethanol 
• 247-66-5 9H-pyrrolo<1,2-a>indole 

Relevant articles and documents

Copper(II)-mediated regioselective N-arylation of pyrroles, indoles, pyrazoles and carbazole via dehydrogenative coupling

A copper(ii)-mediated regioselective N-arylation of azoles has been developed using 8-aminoquinoline amide as a directing group. This reaction shows a broad substrate scope with different azoles such as pyrroles, indoles, pyrazoles and carbazole with good

Active manganese dioxide promoted cyclization of ortho-(1H-pyrrol-1-yl)aryl and heteroaryl carboxylic acids to 5H-pyrrolo[1,2-a][3,1]benzoxazin-5-one derivatives

The hitherto unknown lactone 5H-pyrrolo[1,2-a][3,1]benzoxazin-5-one and six of its substituted derivatives have been prepared by active manganese dioxide promoted oxidative cyclization of the corresponding 2-(1H-pyrrol-1-yl)benzoic acids, under mild conditions, in moderate yields. The method was successfully extended to the cyclization of some ortho-(1H-pyrrol-1-yl)heteroaryl carboxylic acids and 2-(1H-indol-1-yl)benzoic acids.

N-phenylpyrrole: A kinetic, though not thermodynamic preference for dilithiation

Under appropriate conditions the clean preparation of either the α-monolithiated or the o,α-dilithiated derivative of N-phenylpyrrole is possible. In the latter case, the first deprotonation occurs at the α-position. Dimetalation is kinetically but not thermodynamically favored.