60251-89-0

Basic information

• Product Name: TROPYL A ORMULPHENYLACETATE
• Synonyms: TROPYL A ORMULPHENYLACETATE;Tropyl alpha-formylphenylacetate
• CAS NO: 60251-89-0
• Molecular Formula: C17H21NO3
• Molecular Weight: 287.35
• Mol File: 60251-89-0.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: TROPYL A ORMULPHENYLACETATE(CAS DataBase Reference)
• NIST Chemistry Reference: TROPYL A ORMULPHENYLACETATE(60251-89-0)
• EPA Substance Registry System: TROPYL A ORMULPHENYLACETATE(60251-89-0)

Safety Data

• Hazardous Substances Data: 60251-89-0(Hazardous Substances Data)

Usage

General Description

TROPYL A ORMULPHENYLACETATE, also known as tropyl ortho-phenylacetate, is a chemical compound with the molecular formula C13H14O2. It is a derivative of phenylacetic acid and is commonly used in organic synthesis and pharmaceutical research. TROPYL A ORMULPHENYLACETATE has potential applications in the development of new drugs and pharmaceuticals, as well as in other chemical processes requiring the modification of phenylacetic acid derivatives. TROPYL A ORMULPHENYLACETATE is known for its aromatic properties and has been studied for its potential therapeutic effects, particularly in the treatment of certain neurological and psychiatric disorders.

Upstream product

• 5894-79-1 methyl 2-formyl-2-phenylacetate 
• 120-29-6 3-tropanol 
• 55-48-1 (1R,3r,5S)-3-tropoyloxytropanium sulfate 
• 103-82-2 phenylacetic acid 
• 532-24-1 tropinone 
• 542-05-2 acetonedicarboxylic acid 
• 59216-85-2 α-formyl phenyl acetic acid 

Relevant articles and documents

Biochemical and Metabolic Insights into Hyoscyamine Dehydrogenase

Hyoscyamine, a member of the class of compounds known as tropane alkaloids (TAs), is clinically used as an anticholinergic drug. Previous research has predicted that hyoscyamine is produced via the reduction of hyoscyamine aldehyde. In this study, we identified a root-expressed gene from Atropa belladonna, named AbHDH, which encodes a hyoscyamine dehydrogenase involved in the formation of hyoscyamine. Enzymatic assays indicated that AbHDH was able to not only reduce hyoscyamine aldehyde to produce hyoscyamine but also oxidize hyoscyamine to form hyoscyamine aldehyde under different conditions. To elucidate its catalytic mechanism, the crystal structure of AbHDH at a 2.4-? resolution was also determined. Overexpression of AbHDH significantly enhanced the biosynthesis of hyoscyamine and the production of anisodamine and scopolamine in root cultures of A. belladonna. However, suppression of AbHDH using RNAi technology did not reduce the production of hyoscyamine, anisodamine, or scopolamine, though it did increase the accumulation of hyoscyamine aldehyde. In summary, this study provided timely biochemical and metabolic insights into hyoscyamine dehydrogenase, pointing to an alternative, promising way to produce pharmaceutical TAs via metabolic engineering in planta.

Kinetics of oxidation of atropine by K2Cr2O7 in acidic aqueous solutions

Oxidation of atropine (ATN) by K2Cr2O7 has been studied kinetically in aqueous strongly acidic solutions. The kinetics of this reaction was investigated at different temperatures. A constant pH and constant ionic strength were maintained constant throughout all measurements. The concentration of atropine was around an order of magnitude greater than that of K2Cr2O7, that is under pseudo first order kinetics. Rate constants were obtained by monitoring change in absorbance of K2Cr2O7 with time at its predetermined maximum wavelength. Overall rate constant and the orders of the reaction in terms of concentrations of both atropine and K2Cr2O7 were determined. Reaction runs at different temperature allows activation energy of the process to be convoluted from temperature effect on the rate of the reaction. A resonable mechanism for the reaction was proposed in accordance with kinetics results.