5894-79-1Relevant articles and documents
Atropine hapten and synthesis method thereof, antigen, antibody and application
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Paragraph 0037; 0040-0041; 0048; 0050; 0054; 0056, (2020/05/01)
The invention discloses an atropine hapten and a synthesis method thereof, an antigen, an antibody and an immunodetection device which is convenient to use, rapid, simple and convenient to operate, high in sensitivity and accuracy, and capable of measuring atropine on site. The atropine hapten has a structure as shown in a formula (I) which is described in the specification. The atropine hapten provided by the invention is a proper atropine hapten which is prepared by using nortropine as a raw material and can be more fully exposed to an immune system of an animal. The atropine hapten is coupled with a carrier protein to prepare the artificial antigen; and the atropine artificial antigen is used for immunizing animals, and the monoclonal antibody with high specificity to atropine is prepared by adopting a cell fusion technology.
A new method for preparing ipratropine (by machine translation)
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Paragraph 0041, (2017/09/02)
The invention discloses a ipratropine preparation method, comprises the following steps: benzene acetic acid methyl ester (III) as the starting material, the reaction process for preparing substituted α - formyl benzene acetic acid methyl ester (IV); tropine is mellow with methyl bromide reaction to prepare the compound (II); compound (II) with a compound (IV) reaction of compounds (V), compound (V) reduction process of preparing ipratropine anhydride, through the refining preparation ipratropine (VII), the method is simple in operation, high safety, low cost, is more suitable for industrial production. (by machine translation)
Diastereospecific nazarov cyclization of fully substituted dienones: Generation of vicinal all-carbon-atom quaternary stereocenters
Jolit, Anais,Vazquez-Rodriguez, Saleta,Yap, Glenn P. A.,Tius, Marcus A.
supporting information, p. 11102 - 11105 (2013/10/22)
No vacancy: Fully substituted dienones that are highly polarized by a vinylogous carbonate group were found to undergo a remarkably rapid and diastereospecific Nazarov cyclization that led to cyclopentenones with vicinal all-carbon-atom quaternary centers (see example; SEM=2-(trimethylsilyl) ethoxymethyl, Tf=trifluoromethanesulfonyl). Copyright