60301-45-3Relevant academic research and scientific papers
A New Synthesis of Substituted 4-Amino-1,3-thiazoles
Evers, R.
, p. 604 - 608 (2007/10/02)
In the 5-position substituted 4-amino-2-alkylthio-1,3-thiazoles are prepared in good yields from N-nitro-amidino-dithiocarbamates 1 and α-halogen-carbonylcompounds or chloracetonitrile. 1 reacts with 1,3-dichlor-acetone under formation of adequate bis(1,3
Studies of Cyanamide Derivatives. Part 109. A Convenient Method for Preparation of 4-Aminothiazole Compounds from Alkoxythiocarbonylcyanamide Salts
Fuchigami, Toshio,Yeh, Mou-Yung,Nonaka, Tsutomu,Tien, Hsien-Ju
, p. 3851 - 3852 (2007/10/02)
α-Halo derivatives of ketones, ester, and nitrile reacted readily with potassium ethoxythiocarbonylcyanamide to provide the corresponding 4-amino-2-ethoxythiazole compounds in good yields, while α-halo amide did not.In a similar manner, α,α'-dihalo ketone reacted with 2 equiv of alkoxythiocarbonylcyanamide and S-methyl N-cyanocarbamodithioate salts to give the corresponding bis(4-amino-5-thiazolyl) ketones.
