60313-64-6Relevant academic research and scientific papers
Copper and palladium co-catalyzed highly regio-selective 1,2-hydroarylation of terminal 1,3-dienes
Zhang, Rumeng,Li, Qifan,Zhang, Min,Chai, Sida,Duan, Yuqi,Su, Jingfei,Zhao, Qian,Zhang, Chun
supporting information, p. 13551 - 13554 (2020/11/17)
A practical copper and palladium co-catalyzed highly regio-selective hydroarylation of terminal 1,3-dienes has been developed. This chemistry afforded the terminal alkenyl group containing products, which are a kind of versatile precursor for organic synthesis, from 1,3-dienes by a practical one-step reaction. With good functional group tolerance, this protocol could be used to make a series of bio-active compounds using readily accessible starting materials. The mechanism of this reaction was explored by control experiments and kinetics studies. This journal is
Nickel-Catalyzed 1,2-Diarylation of Alkenyl Carboxylates: A Gateway to 1,2,3-Trifunctionalized Building Blocks
Derosa, Joseph,Kang, Taeho,Tran, Van T.,Wisniewski, Steven R.,Karunananda, Malkanthi K.,Jankins, Tanner C.,Xu, Kane L.,Engle, Keary M.
supporting information, p. 1201 - 1205 (2020/01/08)
A nickel-catalyzed conjunctive cross-coupling of alkenyl carboxylic acids, aryl iodides, and aryl/alkenyl boronic esters is reported. The reaction delivers the desired 1,2-diarylated and 1,2-arylalkenylated products with excellent regiocontrol. To demonstrate the synthetic utility of the method, a representative product is prepared on gram scale and then diversified to eight 1,2,3-trifunctionalized building blocks using two-electron and one-electron logic. Using this method, three routes toward bioactive molecules are improved in terms of yield and/or step count. This method represents the first example of catalytic 1,2-diarylation of an alkene directed by a native carboxylate group.
