3669-48-5

Usage

Uses

Used in Pharmaceutical Research and Development:
Ethanone, 1-(4-phenoxyphenyl)-2-phenylis utilized as a key compound in pharmaceutical research and development due to its potential as an antibacterial and antifungal agent. Its pharmacological properties make it a candidate for the development of new drugs targeting a range of microbial infections.
Used in Organic Synthesis:
In the field of organic synthesis, Ethanone, 1-(4-phenoxyphenyl)-2-phenylserves as a valuable intermediate or building block for the synthesis of more complex organic molecules. Its unique structure and reactivity contribute to the creation of novel compounds with potential applications in various industries.
Used in Medicinal Chemistry:
Ethanone, 1-(4-phenoxyphenyl)-2-phenylis employed in medicinal chemistry for its ability to interact with various biological targets. This characteristic makes it a promising candidate for the design and development of new therapeutic agents, particularly in the areas of infectious diseases and other conditions that require targeted interventions.
Used in Drug Discovery:
Ethanone, 1-(4-phenoxyphenyl)-2-phenyl-'s potential in drug discovery is highlighted by its capacity to engage with multiple biological targets, which can lead to the identification of new drug leads or the optimization of existing drug candidates. This makes it a valuable asset in the search for innovative treatments and therapies.

Upstream product

• 101-84-8 diphenylether 
• 103-80-0 phenylacetyl chloride 
• 21218-94-0 methyl 4-phenoxybenzoate 
• 108-88-3 toluene 
• 945761-06-8 N-methoxy-N-methyl-4-phenoxybenzamide 
• 459-57-4 4-fluorobenzaldehyde 
• 6921-34-2 benzylmagnesium chloride 
• 23096-47-1 1-(4-fluorophenyl)-2-phenylethan-1-ol 
• 108-95-2 phenol 

Downstream Products

• 61457-74-7 1-(4-phenoxyphenyl)-2-phenylethane-1,2-dione 
• 60313-18-0 2-Phenyl-1-(p-phenoxyphenyl)-ethanol 
• 1629159-65-4 C₂₀H₁₇NO₂ 
• 1629159-51-8 3-(4-phenoxyphenyl)-2-phenyl-2H-azirine 
• 1629159-58-5 dimethyl 2-(4-phenoxyphenyl)-5-phenyl-1H-pyrrole-3,4-dicarboxylate 
• 60313-02-2 3-(4-Phenoxy-phenyl)-3,4-dihydro-2H-naphthalen-1-one 
• 60313-32-8 1-Phenyl-2-brom-2-(p-phenoxyphenyl)-ethan 
• 60313-48-6 2-[1-(4-Phenoxy-phenyl)-2-phenyl-ethyl]-malonic acid 
• 60313-64-6 3-(4-phenoxyphenyl)-4-phenylbutanoic acid 
• 81580-96-3 1-(p-phenoxyphenyl)-2-phenylethane 

Relevant academic research and scientific papers

Benzylic Aroylation of Toluenes Mediated by a LiN(SiMe3)2/Cs+System

Chemoselective deprotonative functionalization of benzylic C-H bonds is challenging, because the arene ring contains multiple aromatic C(sp2)-H bonds, which can be competitively deprotonated and lead to selectivity issues. Recently it was found that bimetallic [MN(SiMe3)2 M = Li, Na]/Cs+ combinations exhibit excellent benzylic selectivity. Herein, is reported the first deprotonative addition of toluenes to Weinreb amides mediated by LiN(SiMe3)2/CsF for the synthesis of a diverse array of 2-arylacetophenones. Surprisingly, simple methyl benzoates also react with toluenes under similar conditions to form 2-arylacetophenones without double addition to give tertiary alcohol products. This finding greatly increases the practicality and impact of this chemistry. Some challenging substrates with respect to benzylic deprotonations, such as fluoro and methoxy substituted toluenes, are selectively transformed to 2-aryl acetophenones. The value of benzylic deprotonation of 3-fluorotoluene is demonstrated by the synthesis of a key intermediate in the preparation of Polmacoxib.

Exploring Tandem Ruthenium-Catalyzed Hydrogen Transfer and SNAr Chemistry

A hydrogen-transfer strategy for the catalytic functionalization of benzylic alcohols via electronic arene activation, accessing a diverse range of bespoke diaryl ethers and aryl amines in excellent isolated yields (38 examples, 70% average yield), is reported. Taking advantage of the hydrogen-transfer approach, the oxidation level of the functionalized products can be selected by judicious choice of simple and inexpensive additives.

An improved synthesis of bis(cyclopentadienone)

An improved strategy for the synthesis of 3,3′-(oxy-p-phenylene)bis(2,4,5-triphenylcyclopentadienone) was developed, which includes three steps: Friedel-Crafts reaction, oxidation and condensation. Importantly, the use of KMnO4 made the second step simple and efficient, which has potential application to synthesis of bis(cyclopentadienone)s. The course of oxidation has been confirmed by isolated intermediates.