60335-70-8

Basic information

• Product Name: 5,6-dihydro-4-methyl-2-phenyl-2H-pyran
• Synonyms: 5,6-dihydro-4-methyl-2-phenyl-2H-pyran;4-Methyl-6-phenyl-3,6-dihydro-2H-pyran;2H-Pyran, 5,6-dihydro-4-methyl-2-phenyl-;Einecs 262-186-1
• CAS NO: 60335-70-8
• Molecular Formula: C₁₂H₁₄O
• Molecular Weight: 174.23896
• EINECS: 262-186-1
• Mol File: 60335-70-8.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 266.9°C at 760 mmHg
• Flash Point: 111.1°C
• Appearance: /
• Density: 1.007g/cm³
• Vapor Pressure: 0.0138mmHg at 25°C
• Refractive Index: 1.529
• CAS DataBase Reference: 5,6-dihydro-4-methyl-2-phenyl-2H-pyran(CAS DataBase Reference)
• NIST Chemistry Reference: 5,6-dihydro-4-methyl-2-phenyl-2H-pyran(60335-70-8)
• EPA Substance Registry System: 5,6-dihydro-4-methyl-2-phenyl-2H-pyran(60335-70-8)

Safety Data

• Hazardous Substances Data: 60335-70-8(Hazardous Substances Data)

Usage

InChI:InChI=1/C12H14O/c1-10-7-8-13-12(9-10)11-5-3-2-4-6-11/h2-6,9,12H,7-8H2,1H3

Upstream product

• 766-15-4 4,4-dimethyl-1,3-dioxane 
• 100-52-7 benzaldehyde 
• 107-56-2 O,O-diisopropyl hydrogen phosphorodithioate 
• 30094-01-0 β-styrylmagnesium bromide 
• 556-82-1 3-methyl-2-buten-1-ol 
• 763-32-6 2-methyl-1-buten-4-ol 
• 103596-48-1 4-Methyl-2,3,4-trichlorotetrahydropyran 
• 103596-49-2 3,4-dichloro-4-methyltetrahydropyran 
• 34449-33-7 4-methyl-4-chlorotetrahydropyran 
• 16302-35-5 4-methyl-3,6-dihydro-2H-pyran 
• 103596-52-7 (2R,3R,4R)-3,4-Dichloro-4-methyl-2-phenyl-tetrahydro-pyran 
• 58303-59-6 2-phenyl-4,4-dimethyl-1,3-dioxane 

Relevant articles and documents

Synthetic method of aromatic rose ether perfume

The invention discloses a synthesis method of an aromatic rose ether perfume, which comprises the following steps: with benzaldehyde and isopentenol as raw materials and non-strong protonic acid or Lewis acid as a catalyst, completely carrying out a reaction in an inert non-protonic solvent at reflux temperature, and carrying out after-treatment on the obtained reaction mixed solution to obtain 4-methyl-2-phenyl-dihydropyran. According to the method disclosed by the invention, a mild catalyst is adopted; benzaldehyde or isopentenol with the equivalent weight smaller than 1 is used, a solvent azeotropic with water is used for removing water generated in the reaction, the reaction selectivity is improved, and the reaction molar yield can reach about 90%; the method has the advantages of being economical, environmentally friendly, easy and convenient to implement and high in yield and is suitable for large-scale industrial production.

An efficient synthesis of dihydro- and tetrahydropyrans via oxonium-ene cyclization reaction

An efficient method has been developed for the synthesis of 2,3-dihydropyrans and 4-methylenetetrahydropyrans from aldehydes and substituted homoallyl alcohols in benzene mediated by boron trifluoride etherate in good yields. The reaction proceeds via oxonium-ene reaction.

SYNTHESIS OF 4-METHYL-2,3,4-TRICHLOROTETRAHYDROPYRAN AND SEVERAL FEATURES OF THE STEREOCHEMISTRY OF THE NUCLEOPHILIC SUBSTITUTION OF THE α-CHLORINE ATOM

A convenient method has been developed for the synthesis of 4-methyl-2,3,4-trichlorotetrahydropyran by the chlorination of 4-methyl-4-chlorotetrahydropyran, 4-methyl-5,6-dihydro-2H-pyran and its dichloride.A study was carried out on the reactions of 4-methyl-2,3,4-trichlorotetrahydropyran with alcohols, with sodium thiocyanate and Grignard reagents.PMR spectroscopy was used to study the stereochemistry of 4-methyl-2,3,4-trichlorotetrachloropyran and its derivatives, 2-substituted 4-methyl-3,4-dichlorotetrahydropyrans.The dechlorination of these dichloro derivatives by metallic sodium leads to 2,4-disubstituted 5,6-dihydro-2H-pyrans with high regioselectivity