60336-41-6

Basic information

• Product Name: 2-(4-Chlorophenyl)-N-Methylacetamide
• Synonyms: 2-(4-Chlorophenyl)-N-Methylacetamide
• CAS NO: 60336-41-6
• Molecular Formula: C₉H₁₀ClNO
• Molecular Weight: 183.6348
• Mol File: 60336-41-6.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(4-Chlorophenyl)-N-Methylacetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-Chlorophenyl)-N-Methylacetamide(60336-41-6)
• EPA Substance Registry System: 2-(4-Chlorophenyl)-N-Methylacetamide(60336-41-6)

Safety Data

• Hazardous Substances Data: 60336-41-6(Hazardous Substances Data)

Usage

Chemical composition

Consists of a phenyl group with a chlorine substituent and an N-methylacetamide group.

Physical form

White to off-white crystalline solid.

Usage

Served as a pharmaceutical intermediate in the synthesis of various drugs.

Potential properties

Found to have potential analgesic and anti-inflammatory properties, making it a candidate for the development of new pain-relieving medications.

Utility

Structure and properties make it a useful building block in the production of other organic compounds.

Precautions

May pose hazards to human health and the environment if not properly managed.

Upstream product

• 1878-66-6 4-chlorophenylacetic Acid 
• 96-31-1 N,N'-Dimethylurea 
• 52449-43-1 (4-chloro-phenyl)-acetic acid methyl ester 
• 74-89-5 methylamine 
• 25026-34-0 4-chlorophenacetyl chloride 

Downstream Products

• 38171-31-2 N-methyl-2-(4-chlorophenyl)ethylamine 
• 877265-15-1 7-chloro-2-methyl-1,4-dihydro-2H-isoquinolin-3-one 
• 87292-81-7 3-chloro-4-(4-chlorophenyl)-1-methyl-1H-pyrrole-2,5-dione 

Relevant articles and documents

Direct synthesis of amides from nonactivated carboxylic acids using urea as nitrogen source and Mg(NO3)2or imidazole as catalysts

A new method for the direct synthesis of primary and secondary amides from carboxylic acids is described using Mg(NO3)2·6H2O or imidazole as a low-cost and readily available catalyst, and urea as a stable, and easy to manipulate nitrogen source. This methodology is particularly useful for the direct synthesis of primary and methyl amides avoiding the use of ammonia and methylamine gas which can be tedious to manipulate. Furthermore, the transformation does not require the employment of coupling or activating agents which are commonly required.

Preparation of tetrahydroisoquinoline-3-ones via cyclization of phenyl acetamides using eaton's reagent

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