60354-41-8Relevant academic research and scientific papers
An efficient synthesis of 4β and 6α-hydroxylated bile acids
Yoshimura, Teruki,Mahara, Reijiro,Kurosawa, Takao,Ikegawa, Shigeo,Tohma, Masahiko
, p. 52 - 58 (2007/10/02)
An efficient method for the preparation of 4β- and 6α-hydroxylated bile acids has been developed.It involved a highly stereoselective acetoxylation at the 4β and 6α positions of 3- and 7-oxo bile acids, respectively, with lead tetraacetate in the presence of boron trifluoride etherate in acetic acid.Reduction of the resulting α-acetoxy ketones with sodium borohydride or tert-butylamine borane complex, and alkaline hydrolysis, provided the desired bile acids in good yields. Keywords: sterols; bile acid; 4β-hydroxylated bile acid;6α-hydroxylated bile acid; acetoxylation; lead tetraacetate oxidation
