60355-38-6

Upstream product

• 451-40-1 phenyl benzyl ketone 
• 1073-67-2 4-vinylbenzyl chloride 
• 873-73-4 4-n-chlorophenylacetylene 
• 100-52-7 benzaldehyde 
• 53476-32-7 C₂₂H₁₅ClO₂ 
• 1615-02-7 p-chlorocinnamic acid 
• 134-81-6 benzil 
• 99-91-2 para-chloroacetophenone 
• 99275-56-6 4-(4-chloro-phenyl)-1,2-diphenyl-but-2-ene-1,4-dione 
• 1777-56-6 4-chlorobenzoylmethylenetriphenylphosphorane 

Relevant academic research and scientific papers

Base-catalysed [3 + 2] cycloaddition of propargylamines and aldehydes to substituted furans

A base-catalysed [3 + 2] cycloaddition reaction of propargylamines and aldehydes for the regiospecific synthesis of substituted furans under metal-free conditions is developed. Propargylamines are used as allenyl anion equivalents and applied in [3 + 2] cycloaddition reactions with aldehydes. Various substituted furans are provided up to 91% yield for 28 examples.

X-ray Absorption and Electron Paramagnetic Resonance Guided Discovery of the Cu-Catalyzed Synthesis of Multiaryl-Substituted Furans from Aryl Styrene and Ketones Using DMSO as the Oxidant

The first example of DMSO serving not only as a solvent but also as an oxidant to promote the oxidation of Cu(I) to Cu(II) has been demonstrated. X-ray absorption and electron paramagnetic resonance evidence revealed a single-electron redox process where DMSO could oxidize Cu(I) to Cu(II). The novel discovery guided the rational design of copper-catalyzed oxidative cyclization of aryl ketones with styrenes to furans, providing a new method for the synthesis of multiaryl-substituted furans from cheap and readily available starting materials.

A co-operative effect of visible light photo-catalysis and CoFe2O4 nanoparticles for green synthesis of furans in water

A novel approach to poly-functionalized furan synthesis is disclosed via oxidative decarboxylative [3+2] cycloaddition using co-operative catalysis by visible light and CoFe2O4 nanoparticles under ambient reaction conditions with water as a solvent. Although the reported method is efficient without catalyst in the presence of visible light (70% yield in 4 h at rt), the use of catalyst not only increases the yield (91%) but also accelerates the conversion rate (2 h at rt).

Successively recycle waste as catalyst: A one-pot wittig/1,4-reduction/paal-knorr sequence for modular synthesis of substituted furans

A one-pot tandem Wittig/conjugate reduction/Paal-Knorr reaction is reported for the synthesis of di- or trisubstituted furans. This novel sequence first demonstrates the possibility of successively recycling waste from upstream steps to catalyze downstream reactions.

Copper-catalyzed regioselective synthesis of furan via tandem cycloaddition of ketone with an unsaturated carboxylic acid under air

A catalytic decarboxylative annulation has been developed for the regioselective synthesis of trisubstituted furans by the cycloaddition of ketones with α,β-unsaturated carboxylic acids under ambient air. A library of furan derivatives were obtained in good yields from the readily available substrates in the combination of a catalytic amount of Cu-salt and a stoichiometric amount of water. Water plays a crucial role in this catalytic transformation. This journal is

Radical based strategy toward the synthesis of 2,3-dihydrofurans from aryl ketones and aromatic olefins

A copper-mediated annulation of aryl ketones with a wide range of aromatic olefins has been developed. This strategy allowed convenient access to 2,3-dihydrofuran derivatives. The versatility of the protocol is shown by synthesizing α-methyl dihydrofurans, which serve as an intermediate for the synthesis of vitamin B1. In addition, the applicability of the protocol in conjugated systems is demonstrated. A radical pathway was presumed and supported for annulation of aryl ketones with olefins. (Chemical Equation Presented).

Facile Synthesis of Furans From 2-Ene-1,4-diones by Diphosphorus Tetraiodide

Diphosphorus tetraiodide effects reductive ring-closure of a variety of 2-ene-1,4-diones into furans within a few minutes at room temperature.