60374-77-8Relevant academic research and scientific papers
Antitumor activity of C-methyl-β-D-ribofuranosyladenine nucleoside ribonucleotide reductase inhibitors
Franchetti, Palmarisa,Cappellacci, Loredana,Pasqualini, Michela,Petrelli, Riccardo,Vita, Patrizia,Jayaram, Hiremagalur N.,Horvath, Zsuzsanna,Szekeres, Thomas,Grifantini, Mario
, p. 4983 - 4989 (2007/10/03)
A series of adenosine derivatives substituted at the 1′-, 2′-, or 3′-position of the ribose ring with a methyl group was synthesized and evaluated for antitumor activity. From this study 3′-C-methyladenosine (3′-Me-Ado) emerged as the most active compound
EPIMERIZATION DURING THE ACETOLYSIS OF 3-O-ACETYL-5-O-BENZOYL-1,2-O-ISOPROPYLIDENE-3-C-METHYL-α-D-RIBOFURANOSE. SYNTHESIS OF 3'-C-METHYLNUCLEOSIDES WITH THE β-D-ribo- AND α-D-arabino CONFIGURATIONS
Beigelman, Leon N.,Gurskaya, Galina V.,Tsapkina, Elena N.,Mikhajlov, Sergey N.
, p. 77 - 88 (2007/10/02)
Acetolysis of 3-O-acetyl-5-O-benzoyl-1,2-O-isopropylidene-3-C-methyl-α-D-ribofuranose with a high concentration of acetic acid yielded 1,2,3-tri-O-acetyl-5-O-benzoyl-3-C-methyl-D-arabinofuranose, which was used for the preparation of 3-C-methyl-α-D-arabinofuranosyl nucleosides. 3'-C-Methylribonucleosides were also synthesized starting from 1,2,3-tri-O-acetyl-5-O-benzoyl-3-C-C-methyl-D-ribofuranose.
SYNTHESIS AND PROPERTIES OF 3'-C-METHYLNUCLEOSIDES AND THEIR PHOSPHORIC ESTERS
Mikhailov, Sergey N.,Beigelman, Leon N.,Gurskaya, Galyna V.,Padyukova, Nelly Sh.,Yakovlev, Gennady I.,Karpeisky, Marat Ya.
, p. 75 - 96 (2007/10/02)
3'-C-Methyluridine and 3'-C-methylcytidine were synthesized in 11 steps starting from D-glucose.The conformation of 3'-C-methylnucleosides was studied in solution and in the cystal by using the techniques of c.d., 1H-n.m.r spectroscopy, and X-ray diffract
