60378-99-6

Basic information

• Product Name: DIMETHYL-3-CHLORO-2-OXOPROPYLPHOSPHONATE
• Synonyms: DIMETHYL-3-CHLORO-2-OXOPROPYLPHOSPHONATE;Dimethyl-3-chloro-2-oxopropylphosphonate, 96 %
• CAS NO: 60378-99-6
• Molecular Formula: C5H10ClO4P
• Molecular Weight: 200.56
• Mol File: 60378-99-6.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: DIMETHYL-3-CHLORO-2-OXOPROPYLPHOSPHONATE(CAS DataBase Reference)
• NIST Chemistry Reference: DIMETHYL-3-CHLORO-2-OXOPROPYLPHOSPHONATE(60378-99-6)
• EPA Substance Registry System: DIMETHYL-3-CHLORO-2-OXOPROPYLPHOSPHONATE(60378-99-6)

Safety Data

• Hazardous Substances Data: 60378-99-6(Hazardous Substances Data)

Upstream product

• 79-04-9 chloroacetyl chloride 
• 756-79-6 dimethyl methane phosphonate 
• 20485-54-5 1,1-dichloro-3-diazo-propan-2-one 
• 868-85-9 Dimethyl phosphite 
• 20485-55-6 ω-trichlorodiazoacetone 
• 20485-53-4 1-chloro-3-diazopropan-2-one 

Relevant articles and documents

Enantioselective reduction of 2-keto-3-haloalkane phosphonates by Baker's yeast

Bioreduction of 3-substituted-2-oxoalkanephosphonates by baker's yeast afforded 3-substituted-2-hydroxy-alkanephosphonates in moderate to good yields and ee value. These compounds could serve as useful chirons for the stereoselective synthesis of phosphorus analogs of biologically active molecules including R-(-)-3-trimethylammonium-2-hydroxypropanoic acid and R-(-)-3-trimethylammonium-2-hydroxypropanoic acid.

INSERTION OF CARBENES INTO P-H BONDS. 5. SYNTHESIS OF NEW PHOSPHONATES AND PHOSPHINATES IN REACTIONS CATALYSED BY Cu, Pd, Rh, Ni COMPLEXES

Cu(OTf)2 and Cu(acac)2 were found to be the most effective catalysts in the reaction of diazo compounds Ph2CN2 (1a), EtOC(O)CHN2 (1b), MeOC(O)CHN2 (1c), MeC(O)CN2C(O)OMe (1d), ClCH2C(O)CHN2 (1e) and CH2N2 (1f) with hydrophosphoryl compounds (MeO)2P(O)H (2a), (t-BuO)2P(O)H (2b), Ph(MeO)P(O)H (2c), (EtO)2P(O)H (2d) and P(O)H (2e) resulting in P-C bond formations.Cu, Pd and Rh acetates and Ni(acac)2 have a much lower efficiency.Chlorines in Cl3CC(O)CH2P(O)(OMe)2 (3k) and Cl2CHC(O)CH2P(O)(OMe)2 (3l) are reduced in the copper catalysed Atherton-Todd reaction.Key words: Catalyst; diazo compound; hydrophosphoryl compound; insertion; phosphonate; phosphinate.