60380-79-2Relevant academic research and scientific papers
Torsional, rotor, and electronic effects in 4-tert-butylmethylenecyclohexane epoxidations and osmylations
Vedejs,Dent III,Kendall,Oliver
, p. 3556 - 3567 (2007/10/03)
The axial epoxidation preference for 2-substituted 4-tert-butylmethylenecyclohexanes is attributed to a combination of small effects, including existing bond torsion and rotor effects. Contributions from developing bond torsion are smaller and may be negl
Practical hydroxymethylation of aldehydes and ketones via pinacol cross-coupling reactions with paraformaldehyde
Park, Jeonghan,Pedersen, Steven F.
, p. 2069 - 2080 (2007/10/02)
A general and practical method for the direct hydroxymethylation of aldehydes and ketones via pinacol cross-coupling with paraformaldehyde is described. The reaction is promoted by vanadium(II) ions which are conveniently generated from the reduction of VCl3(THF)3 with zinc dust. Excellent yields of terminal diols are obtained and stereoselective coupling is observed with some chiral aldehydes and ketones.
