60385-06-0

Usage

Chemical Properties

clear colorless to light yellow liquid

InChI:InChI=1/C9H9NO2/c1-7-5-8(12-2)3-4-9(7)10-6-11/h3-5H,1-2H3

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 102-50-1 2-methyl-4-methoxyaniline 
• 129822-42-0 N-(tert-butoxycarbonyl)-4-methoxy-2-methylaniline 
• 75-44-5 phosgene 
• 32315-10-9 bis(trichloromethyl) carbonate 

Downstream Products

• 663180-23-2 C₁₁H₁₇N₃O₂ 
• 1627497-88-4 3-(4-methoxy-2-methylphenyl)quinazoline-2,4(1H,3H)-dione 
• 1627497-64-6 2-chloro-3-(4-methoxy-2-methylphenyl)quinazoline-4(3H)-one 
• 896587-22-7 C₁₇H₁₈N₂O₄ 
• 1616413-96-7 6-amino-4-{4-[(4-methoxy-2-methylphenyl)carbamyl]-2-(S)-methylpiperazin-1-yl}-1-methylpyrazolo[3,4-d]pyrimidine 
• 1435954-70-3 4-(5-aminothiazolo[5,4-d]pyrimidin-7-yl)piperazine-1-carboxylic acid (4-methoxy-2-methylphenyl)amide 
• 1435953-67-5 (3R)-4-(5-aminothiazolo[5,4-d]pyrimidin-7-yl)-N-(4-methoxy-2-methyl-phenyl)-3-methyl-piperazine-1-carboxamide 
• 1435953-16-4 (3S)-4-(5-aminothiazolo[5,4-d]pyrimidin-7-yl)-N-(4-methoxy-2-methyl-phenyl)-3-methyl-piperazine-1-carboxamide 

Relevant academic research and scientific papers

Palladium(0)-catalyzed carbon-Hydrogen bond functionalization for the synthesis of indoloquinazolinones

The indoloquinazolinone ring system has attracted considerable attention as a pharmacophore, because it shows various biological activities. The reported synthetic methods for the compound are simple and direct, but are not effective for the direct synthesis of indoloquinazolinone with a methylene group at the C-6 position. A palladium(0)-catalyzed cyclization of chloroquinazolinone via C-H functionalization was developed for a concise synthesis of indoloquinazolinone derivatives. The presence of a substituent at the C-6 position is important for obtaining the product in good yield. The conformation of the reaction intermediate, in particular the N-C-Pd bond angle, is important for the regioselectivity of the reaction.

Fungicidal meta-substituted strobilurin analogs

Strobilurin analogs in which the side chain is in a meta-relationship to the pharmacophore are active fungicides provided an ortho-group is also present. Syntheses, fungicidal screening results and structure-activity relationships for these compounds are described. A new pharmacophore synthesis from aniline precursors is also detailed.

Neue Methode zur Synthese von Isocyanaten unter milden Bedingungen

Keywords: Arendiyldiisocyanate; Di-tert-butyldicarbonat; 4-Dimethylaminopyridin; Isocyanate