604-09-1

Basic information

• Product Name: 17alpha-Hydroxyprogesterone
• Synonyms: 17alpha-Hydoxyprogesterone;Pregn-4-ene-3,20-dione, 17-hydroxy-, (17alpha)-;HYDROXYPROGESTERONE, 17A-;17ALPHA-HYDROXY-4-PREGNENE-3,20-DIONE;17-ALPHA-HYDROXYPREGN-4-ENE-3,20-DIONE;17-HYDROXYPROGESTERONE;17A-HYDROXY-4-PREGNENE-3,20-DIONE;4-PREGNEN-17ALPHA-OL-3,20-DIONE
• CAS NO: 604-09-1
• Molecular Formula: C₂₁H₃₀O₃
• Molecular Weight: 330.46
• EINECS: 200-699-4
• Product Categories: steroids
• Mol File: 604-09-1.mol
• Article Data: 7

Chemical Properties

• Melting Point: 212-215 °C
• Boiling Point: 482.891 °C at 760 mmHg
• Flash Point: 259.95 °C
• Appearance: /
• Density: 1.155 g/cm³
• Vapor Pressure: 2.37E-11mmHg at 25°C
• Refractive Index: 1.56
• Storage Temp.: 2-8°C
• Solubility: Chloroform (Sparingly)
• PKA: 13.03±0.60(Predicted)
• CAS DataBase Reference: 17alpha-Hydroxyprogesterone(CAS DataBase Reference)
• NIST Chemistry Reference: 17alpha-Hydroxyprogesterone(604-09-1)
• EPA Substance Registry System: 17alpha-Hydroxyprogesterone(604-09-1)

Safety Data

• Hazard Codes: T
• Statements: 61
• Safety Statements: 53-22-36/37/39-45
• WGK Germany: 3
• RTECS: TU5060000
• Hazardous Substances Data: 604-09-1(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 604-09-1 differently. You can refer to the following data:
1. 17β-Hydroxyprogesterone is a metabolite of Progesterone. It was isolated from adrenal glands.
2. 17β-Hydroxyprogesterone is a metabolite of Progesterone (P755900). It was isolated from adrenal glands.

InChI:InChI=1/C21H30O3/c1-13(22)21(24)11-8-18-16-5-4-14-12-15(23)6-9-19(14,2)17(16)7-10-20(18,21)3/h12,16-18,24H,4-11H2,1-3H3/t16-,17+,18+,19+,20+,21-/m1/s1

Upstream product

• 888039-75-6 (8R,9S,10R,13S,14S)-17-Ethynyl-17-hydroxy-10,13-dimethyl-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-cyclopenta[a]phenanthren-3-one 
• 434-03-7 levonorgestrel 
• 124-38-9 carbon dioxide 
• 104-63-2 N-Benzylethanolamine 
• 64-17-5 ethanol 

Downstream Products

• 652-69-7 17α,20α-dihydroxy-4-pregnen-3-one 
• 652-69-7 17α,20β-dihydroxy-4-pregnen-3-one 

Relevant articles and documents

Synthesis of Α-hydroxy ketones by copper(I)-catalyzed hydration of propargylic alcohols: CO2 as a cocatalyst under atmospheric pressure

Inexpensive and efficient Cu(I) catalysis is reported for the synthesis of α-hydroxy ketones from propargylic alcohols, CO2, and water via tandem carboxylative cyclization and nucleophilic addition reaction. Notably, hydration of propargylic alcohols can be carried out smoothly under atmospheric CO2 pressure, generating a series of α-hydroxy ketones efficiently and selectively. This strategy shows great potential for the preparation of valuable α-hydroxy ketones by using CO2 as a crucial cocatalyst under mild conditions.

Thermodynamically favorable synthesis of 2-oxazolidinones through silver-catalyzed reaction of propargylic alcohols, CO2, and 2-aminoethanols

Development of catalytic routes to incorporate CO2 into carbonyl compounds at mild conditions remains attractive and challenging. Herein, a one-pot three-component cascade reaction of terminal propargylic alcohols, CO2, and 2-aminoethanols through AgI-based catalysis is reported for the synthesis of carbonyl compounds through C—O/C—N bond formation. This thermodynamically favorable route can be ingeniously regulated to afford a wide range of 2-oxazolidinones along with concurrent production of α-hydroxyl ketone derivatives in excellent yields and selectivity. Preliminary mechanistic studies indicate that such a process proceeds through successive formation of α-alkylidene cyclic carbonate, β-oxopropylcarbamate, and 2-oxazolidinones.

NOVEL OXIDIZING PROPERTIES OF p-METHOXYBENZENETELLURINIC ACID ANHYDRIDE

The title compound has proved to be a mild oxidizing agent like the corresponding telluroxide or tellurone towards thiol, phosphine, thioamide, thiourea, thionoester, and benzylic alcohol.In addition, it serves as a selective catalyst for the hydration of terminal alkyne.