604004-13-9

Basic information

• Product Name: 2-(2-{Butyl-[2-(3-hydroxy-phenyl)-acetyl]-amino}-octanoylamino)-3-(4-fluoro-3-nitro-phenyl)-propionic acid
• CAS NO: 604004-13-9
• Molecular Weight: 559.635
• Mol File: 604004-13-9.mol

Chemical Properties

• CAS DataBase Reference: 2-(2-{Butyl-[2-(3-hydroxy-phenyl)-acetyl]-amino}-octanoylamino)-3-(4-fluoro-3-nitro-phenyl)-propionic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-{Butyl-[2-(3-hydroxy-phenyl)-acetyl]-amino}-octanoylamino)-3-(4-fluoro-3-nitro-phenyl)-propionic acid(604004-13-9)
• EPA Substance Registry System: 2-(2-{Butyl-[2-(3-hydroxy-phenyl)-acetyl]-amino}-octanoylamino)-3-(4-fluoro-3-nitro-phenyl)-propionic acid(604004-13-9)

Safety Data

• Hazardous Substances Data: 604004-13-9(Hazardous Substances Data)

Upstream product

• 621-37-4 m-hydroxyphenylacetic acid 
• 6898-76-6 1-(Butylimino)heptane 
• 389634-81-5 3-(4-fluoro-3-nitro-phenyl)-2-formylamino-propionic acid ethyl ester 
• 111-71-7 heptanal 
• 109-73-9 N-butylamine 
• 604004-12-8 3-(4-fluoro-3-nitro-phenyl)-2-formylamino-propionic acid 

Relevant articles and documents

Rapid and diverse route to natural product-like biaryl ether containing macrocycles

A two-step sequence involving an Ugi four-component reaction and an intramolecular nucleophilic aromatic substitution (SNAr) has been developed for the rapid access to biaryl-ether containing macrocycles. In the course of this study, we documented that ammonium chloride can promote the Ugi-4CR in non-polar aprotic solvent (toluene) without the interference of an alternative Passerini reaction. Solid phase synthesis of macrocycles by this two-step sequence was also developed using polymer (Wang resin) supported α-(4′-fluoro-3′-nitro)phenethyl isocyanoacetate as one of the inputs.

Solid-phase synthesis of natural product-like macrocycles by a sequence of Ugi-4CR and SNAr-based cycloetherification

An on-resin Ugi four-component reaction followed by an intramolecular nucleophilic aromatic substitution (SNAr) has been developed for the rapid access to biaryl-ether containing macrocycles.