604010-56-2

Upstream product

• 107-19-7 propargyl alcohol 
• 93790-54-6 [2-(4-iodophenoxy)ethyl]dimethylamine 
• 540-38-5 p-Iodophenol 

Downstream Products

• 604010-57-3 (2E)-3-{4-[2-(dimethylamino)ethoxy]phenyl}-2,3-diphenylprop-2-en-1-ol 
• 604010-59-5 (2E)-3-{4-[2-(dimethylamino)ethoxy]phenyl}-2,3-diphenylprop-2-en-1-al 
• 604010-60-8 (Z)-2-(4-(1,2-diphenylbuta-1,3-dien-1-yl)phenoxy)-N,N-dimethylethanamine 
• 10540-29-1 tamoxifen 

Relevant academic research and scientific papers

(Z)-tamoxifen and tetrasubstituted alkenes and dienes via a regio- and stereospecific three-component magnesium carbometalation palladium(O) cross-coupling strategy

(Matrix presented) The synthesis of various tetrasubstituted alkenes and dienes in a regio- and stereocontrolled manner is described. This three-component coupling strategy involves the addition of Grignard reagents to propargyl alcohols followed by palladium(O)-mediated cross-coupling with aryl or vinyl halides. This protocol has been applied to the synthesis of (Z)-Tamoxifen and related mimics.