60423-91-8Relevant academic research and scientific papers
Enantioselective Enzymatic Reduction of Acrylic Acids
An, Chihui,Shaw, Megan H.,Tharp, Annika,Verma, Deeptak,Li, Hongming,Wang, Heather,Wang, Xiao
supporting information, p. 8320 - 8325 (2020/11/03)
An ene-reductase (ERED 36) with broad substrate specificity was identified, and optimization studies led to the development of an enzymatic protocol for the reduction of α,β-unsaturated acids under mild, aqueous conditions. The substrate scope includes aromatic- A nd aliphatic-substituted acrylic acids, as well as cyclic α,β-substituted acrylic acids, yielding chiral α-substituted acids with exquisite levels of enantioselectivity (>99% ee).
An 1,2,3-triazole derivative bioisoster of a potent in vitro prostaglandin synthesis inhibitor: Preparation and biological activity
Biagi,Dell'Omodarme,Giorgi,Livi,Scartoni
, p. 91 - 98 (2007/10/02)
This paper reports the preparation of the triazole ester 10, a methylenic bioisoster of an oxygenated compound A, effective inhibitor of the prostaglandin synthesis in vitro. Biological evaluation of 10 and of the corresponding acid 9 shows that the compo
Substituted indenyl acetic acids
-
, (2008/06/13)
New substituted indenyl acetic acids and nontoxic pharmaceutically acceptable amides, esters and salts derived therefrom. The substituted indenyl acetic acids disclosed herein have anit-inflammatory, anti-pyretic and analgesic activity.
