66735-03-3Relevant academic research and scientific papers
An 1,2,3-triazole derivative bioisoster of a potent in vitro prostaglandin synthesis inhibitor: Preparation and biological activity
Biagi,Dell'Omodarme,Giorgi,Livi,Scartoni
, p. 91 - 98 (2007/10/02)
This paper reports the preparation of the triazole ester 10, a methylenic bioisoster of an oxygenated compound A, effective inhibitor of the prostaglandin synthesis in vitro. Biological evaluation of 10 and of the corresponding acid 9 shows that the compo
Conformational Analysis of 1,1,2-Trisubstituted Ethanes by PMR: Part I - 3-Aryl-2-methylpropanols
Somasekharan, K. N.,Kiefer, Edgar F.
, p. 29 - 37 (2007/10/02)
A self-consistent model for the conformational analysis of 1,1,2-trisubstituted ethanes is developed, based on the temperature dependence of vicinal proton-proton coupling constants.Synthesis of racemates of 2(R), 3(S)- and 2(S), 3(R)-2,3-dideutero-2-methyl-3-phenyl-1-propanols is accomplished using known reactions of well-defined stereochemistry.By comparing the PMR spectra of undeuterated and deuterated compounds, an unequivocal assignment of benzylic protons is made.Concentration and variable-temperature studies have revealed the existence of very weak intramolecular interaction in three alcohols, p-R-C6H4-CH2-CHMe-CH2-OH, where R = NO2, H and OMe.
Phenylmercaptotetrazolo- and nitroindazolo masked development/image modifiers
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, (2008/06/13)
Novel nitrobenzyl compounds are incorporated into a photographic emulsion or developer for controlled release of development/image modifier compounds. This occurs imagewise only after developer oxidation products have been formed in the course of the development process. For example, nitrobenzyl-masked phenylmercaptotetrazole (PMT), incorporated into a silver halide emulsion, reacts with developer oxidation products via an electron transfer mechanism to release the potent development restrainer PMT.
