60427-97-6

Upstream product

• 75-09-2 dichloromethane 
• 292638-85-8 acrylic acid methyl ester 
• 17077-46-2 4-(3-phenyl-propionyl)-morpholine 
• 1501-26-4 methyl 4-(chlorocarbonyl)butyrate 
• 3277-89-2 phenethylmagnesium bromide 
• 105769-65-1 C₁₈H₁₈N₂O₄ 
• 64601-12-3 glutaric acid lithium salt 

Downstream Products

• 32764-94-6 7-phenyl-5-oxoheptanoic acid 

Relevant academic research and scientific papers

Enantioselective synthesis of Indolizidines bearing quaternary substituted stereocenters via rhodium-catalyzed [2 + 2 + 2] cycloaddition of alkenyl Isocyanates and terminal alkynes

An enantioselective synthesis of Indolizidines bearing quaternary substituted stereocenters by way of a rhodium-catalyzed [2 + 2 + 2] cycloaddition of substituted alkenyl Isocyanates and terminal alkynes Is described. The reaction provides lactam products using aliphatic alkynes, whereas aryl alkynes give rise to vlnylogous amide products. Through modification of the phosphoramldlte llgand, high levels of enantloselectlvlty, regloselectlvlty, and product selectivity are obtained for both products.

A new entry to 1,5-keto esters and their 4,4-dideuterio derivatives via methylene chloride as methylene dianion equivalents

(Chemical Equation Presented) This TiCl4-Mg promoted multicomponent coupling of various amides with CH2Cl2 and methyl acrylate represents an extremely simple and practical synthesis of 1,5-keto esters. The efficiency of this chemistry is illustrated by the very simple preparation of unusual 4,4-dideuterio- 1,5-keto esters.

REACTION OF (E)-PHENYL 2-PYRIDYL KETONE O-ACYLOXIMES (PPAO) WITH GRIGNARD REAGENTS. A CONVENIENT AND HIGHLY CHEMOSELECTIVE SYNTHESIS OF KETONES

The reaction of (E)-phenyl 2-pyridyl ketone O-acyloximes (PPAO) with Grignard reagents was found to be widely applicable to the chemoselective synthesis of various ketones in good yields under mild conditions.

ONE-POT SYNTHESIS OF KETONES FROM CARBOXYLIC ACIDS AND GRIGNARD REAGENTS USING N,N-DIPHENYL-p-METHOXYPHENYLCHLOROMETHYLENIMINIUM CHLORIDE

N,N-Diphenyl-p-methoxyphenylchloromethyleniminium chloride is found to be an effective condensation reagent of carboxylic acids and Grignard reagents under mild conditions to afford the corresponding ketones in high yields.