604813-07-2

Basic information

• Product Name: N-ETHYL-4-CHLORO-PYRIDINE-2-CARBOXAMIDE
• Synonyms: N-ETHYL-4-CHLORO-PYRIDINE-2-CARBOXAMIDE;4-Chloro-N-ethylpicolinaMide;N-Ethyl 4-chloropicolinaMide;4-Chloro-N-ethylpyridine-2-carboxamide
• CAS NO: 604813-07-2
• Molecular Formula: C8H9ClN2O
• Molecular Weight: 184.62286
• Mol File: 604813-07-2.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 328 °C at 760 mmHg
• Flash Point: 152.1 °C
• Appearance: /
• Density: 1.218 g/cm²
• Vapor Pressure: 0.000195mmHg at 25°C
• Refractive Index: 1.539
• Storage Temp.: 2-8°C
• CAS DataBase Reference: N-ETHYL-4-CHLORO-PYRIDINE-2-CARBOXAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-ETHYL-4-CHLORO-PYRIDINE-2-CARBOXAMIDE(604813-07-2)
• EPA Substance Registry System: N-ETHYL-4-CHLORO-PYRIDINE-2-CARBOXAMIDE(604813-07-2)

Safety Data

• Hazardous Substances Data: 604813-07-2(Hazardous Substances Data)

Usage

General Description

N-ETHYL-4-CHLORO-PYRIDINE-2-CARBOXAMIDE is a chemical compound with the molecular formula C9H10ClN3O. It is a pyridine derivative with a chloro group and an ethyl substituent attached to the nitrogen atom, as well as a carboxamide group in the 2-position of the pyridine ring. N-ETHYL-4-CHLORO-PYRIDINE-2-CARBOXAMIDE is primarily used as an intermediate in the synthesis of various pharmaceuticals and agrochemicals. It has also been found to exhibit certain biological activities, such as antifungal and antibacterial properties, making it a potential candidate for drug development. Additionally, it may have other industrial applications, such as in the production of dyes or pigments. However, due to its potential toxicological and environmental effects, careful handling and disposal of N-ETHYL-4-CHLORO-PYRIDINE-2-CARBOXAMIDE are necessary to minimize any negative impacts.

InChI:InChI=1/C8H9ClN2O/c1-2-10-8(12)7-5-6(9)3-4-11-7/h3-5H,2H2,1H3,(H,10,12)

Upstream product

• 53750-66-6 4-chloro-pyridine-2-carbonyl chloride 
• 75-04-7 ethylamine 
• 24484-93-3 4-Chloro-pyridine-2-carboxylic acid methyl ester 
• 98-98-6 2-Picolinic acid 

Relevant articles and documents

Discovery of novel 2-substituted-4-phenoxypyridine derivatives as potential antitumor agents

A series of 2-substituted-4-phenoxypyridine derivatives were designed, synthesized, and evaluated for their antiproliferative activity against 4 cancer cell lines (A549, HT-29, H460, and U87MG) in vitro. Most compounds showed moderate to excellent potency. Nine tyrosine kinases (c-Met, Flt-3, ALK, VEGFR-2, VEGFR-3, PDGFR-α PDGFR-β c-Kit, and EGFR) were used to evaluate the inhibitory activities with the most promising analogue 39, which showed the Flt-3/c-Met IC50 values of 2.18/2.61 nM. Structure-activity relationship studies indicated that n-Pr served as R1 group showed a higher preference, and stronger mono-EWGs on the phenyl ring (such as R2 = 4-F) was benefited to the potency.

Design, synthesis and biological activities of sorafenib derivatives as antitumor agents

A series of novel sorafenib derivatives, 9a-w, was designed and synthesized in high yields using various substituted anilines, and their antiproliferative activities against HCT116, PC-3 and MDA-MB-231 cell lines were also evaluated and described. All compounds exhibited potent antiproliferative activity against HCT116 and PC-3 cells with IC50 = 2.8-52.0 and 2.2-45.6 μM; compounds 9p and 9q demonstrated competitive antiproliferative activities to sorafenib against all three cancer cell lines, the cytotoxicity of compound 9r is more potent than that of sorafenib. Compounds (9g, 9p, 9q and 9r) were chosen for further evaluation of the anti-angiogenesis activity, and showed the inhibition of sprout formation from aortic ring ex vivo. The structures of all the newly synthesized compounds were determined by 1H NMR, 13C NMR and HRMS.