60498-57-9

Upstream product

• 59483-54-4 3-chloro-2-nitro-aniline 
• 74-88-4 methyl iodide 
• 64182-61-2 1-chloro-3-fluoro-2-nitrobenzene 
• 74-89-5 methylamine 
• 77-78-1 dimethyl sulfate 

Downstream Products

• 1267635-02-8 C₂₀H₂₀ClN₃O₃ 
• 22284-87-3 6-chloro-1-methyl-5-phenyl-1,5-dihydro-benzo[b][1,4]diazepine-2,4-dione 
• 1310699-89-8 N-(3-chloro-2-nitrophenyl)-N-methyl-β-alanine 
• 1310699-71-8 5-methyl-9-phenyl-1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-2-one 
• 1310699-87-6 2-(5-methyl-2-oxo-9-phenyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-1-yl)-N-[(1S)-1-phenylethyl]acetamide 
• 1332848-59-5 (5-methyl-2-oxo-9-phenyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-1-yl)acetic acid 
• 1310699-84-3 2-(9-chloro-5-methyl-2-oxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-1-yl)-N-[(1S)-1-phenylethyl]acetamide 
• 1310699-82-1 methyl (5-methyl-2-oxo-9-phenyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-1-yl)acetate 

Relevant academic research and scientific papers

Synthesis and NMR spectroscopic assignment of chlorinated benzimidazole-2-thione derivatives

The benzimidazole-2-thione scaffold is present in many drugs encompassing various therapeutic areas. Due to the broad spectrum of bioactivities it also represents an important starting point in drug discovery campaigns, especially those based on fragment-

SOMATOSTATIN MODULATORS AND USES THEREOF

Described herein are compounds that are somatostatin modulators, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders that would benefit from modulation of somatostatin activity.

Discovery of a 1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione series of inhibitors of HIV-1 capsid assembly

The discovery of a 1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione series of inhibitors of HIV-1 capsid assembly is described. Synthesis of analogs of the 1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione hit established structure-activity relationships. Replacement of the enamine functionality of the hit series with either an imidazole or a pyrazole ring led to compounds that inhibited both capsid assembly and reverse transcriptase. Optimization of the bicyclic benzodiazepine scaffold to include a 3-phenyl substituent led to lead compound 48, a pure capsid assembly inhibitor with improved antiviral activity.

Bicyclic Benzimidazole Compounds and Their Use as Metabotropic Glutamate Receptor Potentiators

Compounds of Formula I: wherein A, B, D, L, R1, R2, R3, R4, m, and n are as defined for Formula I in the description. The invention also relates to processes for the preparation of the compounds and to new intermediates employed in the preparation, pharmaceutical compositions containing the compounds, and to the use of the compounds in therapy.

SUBSTITUTED THIOPHENE DERIVATIVES AS ANTI-CANCER AGENTS

The present invention relates to new substituted five-membered compounds and pharmaceutically acceptable salts, esters or prodrugs thereof, compositions of the new compounds together with pharmaceutically acceptable carriers, and uses of the new compounds