60504-57-6Relevant articles and documents
Doxorubicin and Aclarubicin: Shuffling Anthracycline Glycans for Improved Anticancer Agents
Wander, Dennis P. A.,Van Der Zanden, Sabina Y.,Van Der Marel, Gijsbert A.,Overkleeft, Herman S.,Neefjes, Jacques,Codée, Jeroen D. C.
, p. 12814 - 12829 (2020/11/17)
Anthracycline anticancer drugs doxorubicin and aclarubicin have been used in the clinic for several decades to treat various cancers. Although closely related structures, their molecular mode of action diverges, which is reflected in their biological activity profile. For a better understanding of the structure-function relationship of these drugs, we synthesized ten doxorubicin/aclarubicin hybrids varying in three distinct features: Aglycon, glycan, and amine substitution pattern. We continued to evaluate their capacity to induce DNA breaks, histone eviction, and relocated topoisomerase IIα in living cells. Furthermore, we assessed their cytotoxicity in various human tumor cell lines. Our findings underscore that histone eviction alone, rather than DNA breaks, contributes strongly to the overall cytotoxicity of anthracyclines, and structures containing N,N-dimethylamine at the reducing sugar prove that are more cytotoxic than their nonmethylated counterparts. This structural information will support further development of novel anthracycline variants with improved anticancer activity.
Practical Total Synthesis of (+/-)-Aklavinone and Total Synthesis of Aklavin
Pearlman, B. A.,McNamara, J. M.,Hasan, I.,Hatakeyama, S.,Sekizaki, H.,Kishi, Y.
, p. 4248 - 4251 (2007/10/02)
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