60509-67-3

Upstream product

• 6852-58-0 (E)-N-benzylidene-2-methylpropan-2-amine 
• 100-52-7 benzaldehyde 
• 6852-58-0 N-benzylidene tert-butylamine 

Relevant academic research and scientific papers

A Metal-Free Approach to 1,2-Diamines via Visible Light-Driven Reductive Coupling of Imines with Perylene as a Photoredox Catalyst

A simple, metal-free, and versatile approach to 1,2-diamines has been developed based on reductive coupling reactions of various imines, where perylene, an aromatic hydrocarbon, was used as a photoredox catalyst under visible light irradiation using a white light-emitting diode. The use of 1 mol % perylene enabled almost complete conversion of the imines, leading to the formation of their corresponding 1,2-diamines, which were isolated in good yields. The ratios between dl and meso diamines ranged from 31:69 to 82:18 depending on the substituents of the imines.

Zn-mediated catalytic photoreduction of aldimines. One-pot synthesis and separation of meso and d,l C2 symmetrical diamines

A new one-pot method for the synthesis and selective separation of 1,2-diamines is reported. The methodology, which involves the photoreduction of imines using catalytic amounts of zinc as a photosensitizer, allows the direct preparation and separation of meso and d,l compounds on a multigram scale.

Synthesis of enantiomerically pure C2-symmetric acyclic and cyclic 1,2-diamines via pinacol coupling of imines

The inter- and intramolecular coupling of imines promoted by samarium diiodide and Lewis acids or by Zn/MsOH was extensively studied. The intramolecular reaction of chiral, enantiomerically pure bis-imines was also considered, and allowed the efficient, s

Reductive coupling of aromatic aldehydes and imines by the low valent titanium species generated in the reaction of TiCl4 with Et3N

Aromatic aldehydes and imines are converted to the corresponding diols and diamines using the low valent titanium species generated by the reaction of TiCl4 with triethylamine.

Diastereoselective synthesis of 1,2-diphenyl-1,2-diaminoethanes by Yb(OTf)3 accelerated reductive coupling of imines

New reaction protocols have been established to perform the reductive coupling of N-benzyl benzaldimines to 1,2-diphenyl-1,2-diaminoethanes in mild, stereoselective, and catalytic conditions by the use of SmI2 and Yb(OTf)3.

Titanium Induced Coupling of Imines to Symmetrical Vicinal (R*,R*)-Diamines

Symmetrical vicinal (R*,R*) -d,l-diamines were prepared from the corresponding imines and low valent titanium species generated by the action of titanium tetrachloride on amalgamated magnesium.