60512-80-3

Basic information

• Product Name: 1-(2,4-dimethoxy-3-methyl-phenyl)ethanone
• Synonyms: 2',4'-dimethoxy-3'-acetophenone;Acetophenone, 2',4'-dimethoxy-3'-methyl-;Nsc156899;Ethanone, 1-(2,4-diMethoxy-3-Methylphenyl)-;2',4'-DIMETHOXY-3'-METHYL-ACETOPHENONE
• CAS NO: 60512-80-3
• Molecular Formula: C₁₁H₁₄O₃
• Molecular Weight: 194.23
• Mol File: 60512-80-3.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 311.7°C at 760 mmHg
• Flash Point: 133.2°C
• Appearance: /
• Density: 1.048g/cm³
• Vapor Pressure: 0.000556mmHg at 25°C
• Refractive Index: 1.499
• CAS DataBase Reference: 1-(2,4-dimethoxy-3-methyl-phenyl)ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2,4-dimethoxy-3-methyl-phenyl)ethanone(60512-80-3)
• EPA Substance Registry System: 1-(2,4-dimethoxy-3-methyl-phenyl)ethanone(60512-80-3)

Safety Data

• Hazardous Substances Data: 60512-80-3(Hazardous Substances Data)

Usage

General Description

1-(2,4-dimethoxy-3-methyl-phenyl)ethanone, also known as "veratraldehyde," is a chemical compound with the molecular formula C11H14O3. It is a white crystalline solid that is commonly used as a fragrance and flavoring agent in the production of perfumes, soaps, and cosmetics. Veratraldehyde is also used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. Additionally, it has been investigated for its potential use as an anti-inflammatory agent and as a precursor for the production of polymers and resins. Veratraldehyde has a sweet, vanillin-like odor and is considered to be relatively safe for use in consumer products when used in accordance with regulations.

InChI:InChI=1/C11H14O3/c1-7-10(13-3)6-5-9(8(2)12)11(7)14-4/h5-6H,1-4H3

Upstream product

• 118824-97-8 4'-Hydroxy-2'-methoxy-3'-methylacetophenone 
• 74-88-4 methyl iodide 
• 5673-07-4 2,6-dimethoxytoluene 
• 608-25-3 2-methylbenzene-1,3-diol 
• 10139-84-1 1-(2,4-dihydroxy-3-methylphenyl)ethanone 
• 69469-91-6 1-(2-hydroxy-4-methoxy-3-methylphenyl)ethanone 
• 77-78-1 dimethyl sulfate 
• 75-36-5 acetyl chloride 

Downstream Products

• 96502-90-8 acetic acid 2,4-dimethoxy-3-methyl-phenyl ester 
• 19676-67-6 2,4-dimethoxy-3-methylphenol 
• 111223-14-4 5-amino-2,4-dimethoxy-3-methylphenol 
• 136763-93-4 2,4-dimethoxy-3-methyl-5-nitrophenol 
• 192188-84-4 acetic acid 2,4-dimethoxy-3-methyl-5-nitrophenyl ester 
• 115920-44-0 carbazomycin G 
• 115920-42-8 1,4-dihydro-1-hydroxy-3,6-dimethoxy-1,2-dimethyl-9H-carbazol-4-one 
• 1373494-91-7 C₁₇H₁₃BrO₄ 
• 1373494-83-7 C₁₇H₁₃ClO₄ 
• 1373494-94-0 1-(3-bromo-4,6-dihydroxy-5-methyl-2-(2-phenylethynyl)phenyl)ethanone 
• 1373494-89-3 1-(3-chloro-4,6-dihydroxy-5-methyl-2-(2-phenylethynyl)phenyl)ethanone 
• 1373494-88-2 1-(2,4-dihydroxy-3-methyl-6-(2-phenylethynyl)phenyl)ethanone 
• 1373494-87-1 1-(6-bromo-2,4-dihydroxy-3-methylphenyl)ethanone 
• 1373494-86-0 1-(6-bromo-2,4-dimethoxy-3-methylphenyl)ethanone 

Relevant articles and documents

Iridium-Catalyzed C(sp3)?H Addition of Methyl Ethers across Intramolecular Carbon–Carbon Double Bonds Giving 2,3-Dihydrobenzofurans

Intramolecular addition of an O-methyl C(sp3)?H bond across a carbon-carbon double bond occurs in the iridium-catalyzed reaction of methyl 2-(propen-2-yl)phenyl ethers. The Ir/(S)-DTBM-SEGPHOS catalyst promotes the reaction efficiently in toluene at 110–135 °C to afford 3,3-dimethyl-2,3-dihydrobenzofurans. Enantioselective C(sp3)?H addition is achieved in the reaction of methyl 2-(1-siloxyethenyl)phenyl ethers, affording enantioenriched 3-hydroxy-2,3-dihydrobenzofuran derivatives with up to 96% ee. (Figure presented.).

New Drug Delivery System for Crossing the Blood Brain Barrier

New ubiquinol analogs are disclosed, as well as methods of using these compounds to deliver drug moieties to the body.

Access to orthogonal protected phenols - Synthesis of a silylated quinol

Herein we describe the synthesis of t-butyldimethylsilyl protected quinol (9), using an oxidation/reduction sequence to create the desired orthogonality. The title compound acts as a synthetic equivalent for a quinone, required in the total synthesis of E