60532-55-0Relevant academic research and scientific papers
New efficient synthesis of 1,4-benzodiazepin-5-ones by catalytic aza-Wittig reaction
Wang, Long,Qin, Ru-Qing,Yan, Hong-Ye,Ding, Ming-Wu
, p. 3522 - 3528 (2015/11/17)
1,4-Benzodiazepin-5-ones were synthesized in 71-89% yields from 2-isocyanato-N-(2-oxoalkyl)benzamides via a new catalytic intramolecular aza-Wittig reaction. Starting from easily accessible phthalic anhydride and α-arylamino ketones, the corresponding 2-{[(2-oxoalkyl)amino]carbonyl}benzoic acids underwent sequential formation of the acid azide and Curtis rearrangement to give 2-isocyanato-N-(2-oxoalkyl)benzamides that were reacted directly to give the final 2,4-diaryl-3,4-dihydro-5H-1,4-benzodiazepin-5-ones and 4-aryl-2-tert-butyl-3,4-dihydro-5H-1,4-benzodiazepin-5-ones.
Synthesis, antibacterial activity and binding mode analysis of some novel 1,4-diaryl imidazole thiones
Ganguly, Swastika,Singh, Nalini,Upadhyay, Arpita
, p. 419 - 424 (2019/01/21)
A novel series of fifteen diaryl imidazole thiones 2a-o was synthesized by reacting the corresponding 1-(aryl)-2-(arylamino)-ethanones 1 with ammonium thiocyanate. The compounds have been characterized on the basis of elemental analysis and spectral data.
Microwave-assisted, solvent-free Bischler indole synthesis
Sridharan, Vellaisamy,Perumal, Subbu,Avenda?o, Carmen,Menéndez, J. Carlos
, p. 91 - 95 (2007/10/03)
The solid-state reaction between anilines and phenacyl bromides in the presence of an equimolecular amount of sodium bicarbonate gives N-phenacylanilines. Microwave irradiation of mixtures of these compounds with anilinium bromides at 540 W for 45-60 s provides a mild, general, and environmentally friendly method for the synthesis of 2-arylindoles in 50-56% overall yields. A one-pot variation of the method, involving irradiation of 2:1 mixtures of anilines and phenacyl bromides, was also developed, allowing a simplified experimental procedure and leading to improved yields (52-75%). Georg Thieme Verlag Stuttgart.
Hypervalent iodine mediated syntheses of heterocycles: One-pot facile syntheses of 1,4-diaryl-2-mercaptoimidazoles, 2-(α-anilinoacetyl)thiophenes and 1-aryl-2-mercapto-4-(2-thienyl)imidazoles from aryl/2-thienyl methyl ketones
Prakash, Om,Ranjana,Saini, Neena,Goyal, Seema,Tomar, Rajesh K.,Singh, Shiv P.
, p. 116 - 119 (2007/10/02)
Successive treatment of acetophenones (1a-e) or 2-acetylthiophene (4) with benzene, appropriate aniline and KSCN/AcOH leads to the formation of 1,4-diaryl-2-mercaptoimidazoles (3aa-3ea) or 1-aryl-2-mercapto-4-(2-thienyl)imidazoles (6a-f) respectively.This procedure also provides 2(α-anilinoacetyl)thiophenes (5a-f) in one pot from 4.
PREPARATION OF NEW THIOHYDROXAMIC ACID DERIVATIVES: SYNTHESIS OF SUBSTITUTED 1-HYDROXY-1,2-DIHYDROIMIDAZOLE-2-THIONES
Barton, Derek H. R.,Chern, Ching-Yu,Tachdjian, Catherine
, p. 793 - 806 (2007/10/02)
A general method for the synthesis of the title compounds is reported.The N-phenacylarylamines (11), prepared from the corresponding phenacyl bromides (9) and arylamines (10), give the thiono (or dithio) carbamates (12) on treatment with phenoxythionocarb
Research on antibacterial and antifungal agents. VIII. Synthesis and antimicrobial activity of 1,4-diarylpyrroles
Porretta,Biava,Fioravanti,Fischetti,Melino,Venza,Bolle,Tita
, p. 717 - 722 (2007/10/02)
The synthesis and the antimicrobial activity of 1,4-diarylpyrroles are reported. The obtained data in comparison with pyrrolnitrin show that many acid derivatives 4 exhibit a selective activity against some strains of Candida spp and poor activity against
Nucleophilic Substitution Reactions of Phenacyl Benzenesulphonates with Anilines in Methanol-Acetonitrile Mixtures
Lee, Ikchoon,Shim, Chang Sub,Chung, Soo Young,Lee, Hai Whang
, p. 975 - 982 (2007/10/02)
The nucleophilic substitution reactions of phenacyl benzenesulphonates with anilines in methanol-acetonitrile have been studied.A stronger nucleophile was found to cause less bond cleavage, while a better leaving group led to less bond formation, in compl
