60541-89-1Relevant academic research and scientific papers
Hydroxylated 1,2,4-oxadiazole benzoic acid compounds, composistions thereof and the use for nonsense suppression
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Page/Page column 19, (2008/12/06)
Novel hydroxylated 1,2,4-oxadiazole benzoic acid compounds, methods of using and pharmaceutical compositions comprising a hydroxylated 1,2,4-oxadiazole benzoic acid derivative are disclosed. The methods include methods of treating or preventing a disease
Enforcing periodic secondary structures in hybrid peptides: A novel hybrid foldamer containing periodic γ-turn motifs
Baruah, Pranjal K.,Sreedevi,Gonnade, Rajesh,Ravindranathan, Sapna,Damodaran, Krishnan,Hofmann, Hans-Joerg,Sanjayan, Gangadhar J.
, p. 636 - 639 (2007/10/03)
This note describes the design, synthesis, and conformational studies of a novel hybrid foldamer that adopts a definite compact, three-dimensional structure determined by a combined effect of the special conformational properties of the foldamer constituents. The striking feature of this de novo designed foldamer is its ability to display periodic γ-turn conformations stabilized by intramolecular hydrogen bonds. Conformational investigations by single-crystal X-ray studies, solution-state NMR, and ab initio MO theory at the HF/6-31G* level strongly support the prevalence of γ-turn motifs in both the di- and tetrapeptide foldamers, which are presumably stabilized by bifurcated hydrogen bonds in the solid and solution states. The strategy disclosed herein for the construction of hybrid foldamers with periodic γ-turn motifs has the potential to significantly augment the conformational space available for foldamer design with diverse backbone structures and conformations.
