60611-95-2

Usage

Uses

Used in Pharmaceutical Industry:
(E)-ETHYL 4-(4-FLUOROPHENYL)-4-OXOBUT-2-ENOATE is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its role in this industry is crucial for the development of new drugs and medications, contributing to the advancement of healthcare and treatment options.
Used in Agrochemical Industry:
In the agrochemical sector, (E)-ETHYL 4-(4-FLUOROPHENYL)-4-OXOBUT-2-ENOATE serves as an intermediate for the production of different agrochemicals. Its application in this industry aids in the development of products that protect crops from pests and diseases, ensuring food security and agricultural productivity.
Overall, (E)-ETHYL 4-(4-FLUOROPHENYL)-4-OXOBUT-2-ENOATE plays a significant role in both the pharmaceutical and agrochemical industries, acting as an essential intermediate in the synthesis of various compounds. However, its potential hazards and flammability necessitate careful handling and storage to prevent accidents and ensure safety.

InChI:InChI=1/C12H11FO3/c1-2-16-12(15)8-7-11(14)9-3-5-10(13)6-4-9/h3-8H,2H2,1H3/b8-7+

Upstream product

• 64-17-5 ethanol 
• 777-15-1 4-(4-fluorophenyl)-4-oxobut-2-enoic acid 
• 462-06-6 fluorobenzene 

Downstream Products

• 1310585-12-6 C₂₉H₂₇FN₂O₄ 
• 1383731-02-9 (Z)-ethyl 4-((diethoxyphosphoryl)oxy)-4-(4-fluorophenyl)but-3-enoate 
• 1283748-92-4 ethyl 3-chloro-4-(4-fluorophenyl)-2-(4-methylphenylsulfonamido)-4-oxobutanoate 

Relevant academic research and scientific papers

Synthesis of 1,5-benzodiazepine derivatives using p-toluenesulfonic acid as catalyst

A series of substituted ethyl 4-oxo-4-phenylbut-2-enoates were prepared and reacted with substituted o-phenylenediamine, undergone Michael addition reactions and cyclodehydration to provide novel 4-phenyl-2,3-dihydro-1,5-benzodiazepine-2-carboxylate derivatives with excellent yields. The synthetic protocol fulfilled many green-chemical requirements by using simple catalyst p-toluenesulfonic acid as activator and ethanol as solvent at room temperature.

Structure-activity relationship, cytotoxicity and mode of action of 2-ester-substituted 1,5-benzothiazepines as potent antifungal agents

Our studies examined the structural features responsible for the antifungal activity of 2-ethoxycarbonyl-1,5-benzothiazepine (7a). Three series of 1,5-benzothiazepine derivatives were synthesized and screened for their antifungal activity. The results suggested that the ethoxycarbonyl group at the 2 position and the imine moiety on the seven-membered ring are essential for activity. The most potent of the synthesized analogues (7a, 7b) were further studied by evaluating their cytotoxicity and mode of action (for 7a). The results showed that compounds 7a and 7b were relatively safe for BV2 cells, but compound 7a interfered with Cryptococcus neoformans cell wall integrity by increasing the chitinase activity. Therefore, compound 7a was considered safe as an antifungal agent for animal cells. Three series of 1,5-benzothiazepine derivatives were synthesized and their antifungal activities were evaluated to determine the structure-activity relationships with respect to the antifungal activity of 2-ester-substituted 1,5-benzothiazepines. The effective antifungal compounds 7a and 7b were further studied for their antifungal activity, cytotoxicity and mechanism of action (for compound 7a). The results provided important information about this class of benzothiazepines. Copyright