777-15-1

Basic information

• Product Name: Z-4-(4-FLUORO-PHENYL)-4-OXO-BUT-2-ENOIC ACID
• Synonyms: (E)-4-(4-fluorophenyl)-4-keto-but-2-enoic acid;2-BUTENOIC ACID, 4-(4-FLUOROPHENYL)-4-OXO-, (E)-;4-(4-fluorophenyl)-4-keto-but-2-enoic acid;Acide (E)4-(4-fluorophenyl)-4-oxo 2-butenique [French];Z-4-(4-FLUORO-PHENYL)-4-OXO-BUT-2-ENOIC ACID;(E)-4-(4-Fluorophenyl)-4-oxobut-2-enoic acid
• CAS NO: 777-15-1
• Molecular Formula: C₁₀H₇FO₃
• Molecular Weight: 194.1591832
• Mol File: 777-15-1.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 347.9°C at 760 mmHg
• Flash Point: 164.2°C
• Appearance: /
• Density: 1.325g/cm³
• Vapor Pressure: 1.97E-05mmHg at 25°C
• Refractive Index: 1.557
• CAS DataBase Reference: Z-4-(4-FLUORO-PHENYL)-4-OXO-BUT-2-ENOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: Z-4-(4-FLUORO-PHENYL)-4-OXO-BUT-2-ENOIC ACID(777-15-1)
• EPA Substance Registry System: Z-4-(4-FLUORO-PHENYL)-4-OXO-BUT-2-ENOIC ACID(777-15-1)

Safety Data

• Hazardous Substances Data: 777-15-1(Hazardous Substances Data)

Usage

General Description

Z-4-(4-FLUORO-PHENYL)-4-OXO-BUT-2-ENOIC ACID, also known as 4-(4-fluorophenyl)-4-oxobut-2-enoic acid, is a chemical compound with the molecular formula C10H7FO3. It is a derivative of butene-4-ethanoic acid and is characterized by the presence of a fluoro-substituted phenyl group and a ketone group on the butene chain. Z-4-(4-FLUORO-PHENYL)-4-OXO-BUT-2-ENOIC ACID is used in organic synthesis and pharmaceutical research as a building block for the production of other compounds. Its properties and potential applications in various fields make it a subject of interest in the chemical and pharmaceutical industries.

InChI:InChI=1/C10H7FO3/c11-8-3-1-7(2-4-8)9(12)5-6-10(13)14/h1-6H,(H,13,14)/b6-5+

Upstream product

• 403-42-9 1-(4-fluorophenyl)ethanone 
• 298-12-4 Glyoxilic acid 
• 108-31-6 maleic anhydride 
• 462-06-6 fluorobenzene 

Downstream Products

• 1018155-46-8 5-[2-(4-fluorophenyl)-2-oxoethyl]-2-[5-(4-methoxyphenyl)-3-phenyl-4,5-dihydropyrazol-1-yl]thiazol-4-one 
• 60611-95-2 ethyl 4-(4-fluorophenyl)-4-oxobut-2-enoate 
• 1018166-34-1 6-(4-fluorobenzoyl)-3,5-dihydro-2H-thiopyrano[2,3-d][1,3]thiazol-2-one 
• 75738-80-6 (+)-(S)-γ-(4-fluorophenyl)-γ-butyrolactone 
• 75738-79-3 (+)-(R)-γ-(4-fluorophenyl)-γ-butyrolactone 
• 51787-96-3 5-(4-fluorophenyl)dihydrofuran-2(3H)-one 
• 28081-19-8 (E)-3-(4-(dimethylamino)phenyl)-1-(4-fluorophenyl)-2-propen-1-one 

Relevant articles and documents

Synthesis of chiral γ-lactones via a RuPHOX-Ru catalyzed asymmetric hydrogenation of aroylacrylic acids

An asymmetric hydrogenation of aroylacrylic acids catalyzed by RuPHOX-Ru catalyst has been developed, affording the corresponding chiral γ-lactones in high yields and with up to 93% ee. The methodology has the advantage of utilizing easily accessible substrates and has therefore expand the scope of the resulting chiral γ-lactones. Furthermore, high catalytic efficiency was achieved in that the reduction of both the C[dbnd]C and C[dbnd]O double bonds was achieved in one step. The current work provides an alternative and convenient pathway for the synthesis of a wide range of chiral γ-lactones.

Pyridazinone substituted benzenesulfonamides as potent carbonic anhydrase inhibitors

A series of sulfonamide derivatives (2a-l) incorporating substituted pyridazinone moieties were investigated for the inhibition of two human cytosolic carbonic anhydrase isoforms, hCA I and hCA II. All these compounds, together with the clinically used su

Structure-activity relationship, cytotoxicity and mode of action of 2-ester-substituted 1,5-benzothiazepines as potent antifungal agents

Our studies examined the structural features responsible for the antifungal activity of 2-ethoxycarbonyl-1,5-benzothiazepine (7a). Three series of 1,5-benzothiazepine derivatives were synthesized and screened for their antifungal activity. The results suggested that the ethoxycarbonyl group at the 2 position and the imine moiety on the seven-membered ring are essential for activity. The most potent of the synthesized analogues (7a, 7b) were further studied by evaluating their cytotoxicity and mode of action (for 7a). The results showed that compounds 7a and 7b were relatively safe for BV2 cells, but compound 7a interfered with Cryptococcus neoformans cell wall integrity by increasing the chitinase activity. Therefore, compound 7a was considered safe as an antifungal agent for animal cells. Three series of 1,5-benzothiazepine derivatives were synthesized and their antifungal activities were evaluated to determine the structure-activity relationships with respect to the antifungal activity of 2-ester-substituted 1,5-benzothiazepines. The effective antifungal compounds 7a and 7b were further studied for their antifungal activity, cytotoxicity and mechanism of action (for compound 7a). The results provided important information about this class of benzothiazepines. Copyright