60629-92-7

Usage

Uses

Used in Pharmaceutical Industry:
1,1-Dicyclopropanecarboxylic Acid is used as a chemical intermediate for the synthesis of various pharmaceutical compounds. Its unique structure with two cyclopropane rings and a carboxylic group provides versatility in the development of new drugs and medicinal agents.
1,1-Dicyclopropanecarboxylic Acid is used as a building block for the creation of novel drug molecules, facilitating the design of pharmaceuticals with specific therapeutic properties and improved pharmacokinetics. Its presence in the synthesis process can contribute to the enhancement of drug efficacy, selectivity, and bioavailability.

Upstream product

• 60629-91-6 <1,1'-Bicyclopropyl>-1-carbonitril 
• 1447944-40-2 dicyclo-propylbenzyl ester 
• 1447944-39-9 benzyl 1-vinylcyclopropanecarboxylate 
• 664364-37-8 benzyl 1-acetylcyclopropanecarboxylate 
• 124-38-9 carbon dioxide 
• 60629-95-0 1-bromo-1-cyclopropylcyclopropane 
• 60629-90-5 3-cyclopropyl-4,5-dihydro-3H-pyrazole-3-carbonitrile 

Downstream Products

• 60629-93-8 1,1'-Bicyclopropyl-1-carbonsaeure-methylester 

Relevant academic research and scientific papers

Scalable synthesis of (1-cyclopropyl)cyclopropylamine hydrochloride

1-Cyclopropylcyclopropanecarboxylic acid (2), which is accessible on a large scale (900 mmol) from 1-bromo-1-cyclopropylcyclopropane (1) in 64% yield (89% on a 12.4 mmol scale), has been subjected to a Curtius degradation employing the Weinstock protocol to furnish the N-Boc-protected (1-cyclopropyl)cyclopropylamine 3 (76%). Deprotection of 3 with hydrogen chloride in diethyl ether gave the (1-cyclopropyl)cyclopropylamine hydrochloride (4?HCl) in 87% yield.

COMBINATIONS OF HEPATITIS C VIRUS INHIBITORS

The present disclosure is generally directed to antiviral compounds, and more specifically directed to combinations of compounds which can inhibit the function of the NS5A protein encoded by Hepatitis C virus (HCV), compositions comprising such combinations, and methods for inhibiting the function of the NS5A protein.

Convenient access to various 1-cyclopropylcyclopropane derivatives

1-Bromo-1-cyclopropylcyclopropane (1), which is easily accessible in two steps from methyl cyclopropanecarboxylate, does not form a stable Grignard reagent: upon reaction with elemental magnesium, yet it readily undergoes bromine/ lithium exchange without rearrangement upon treatment with tert-butyllithium in diethyl ether/pentane at -78 °C, and the resulting 1-lithio-1-cyclopropylcyclopropane can be trapped with various electrophiles to give the correspondingly 1-substituted bicyclopropyl derivatives 10 in yields ranging from 38 to over 90 % (13 examples). The (1-cyclopropylcyclopropyl) boronate 10m, which is also obtained from the 1-lithio derivative, has been subjected to Suzuki cross couplings with a number of aryl halides to furnish 1-aryl-1,1′bicyclopropyl compounds 11 (4 examples, 14-50% yield), predominantly without rearrangement. Further transformations of 1-cyclopropylcyclopropanecarbaldehyde (10e) have provided 2-(1- cyclopropylcyclopropyl)glycme (16), ethyl 3-(1-cyclopropylcyclopropyl)acrylate (17), and its cycloadducts with the nitrone 18 and cyclopentadiene 19, albeit the latter only in poor yield.