60636-79-5Relevant academic research and scientific papers
Copper-mediated synthesis of coumestans via C(sp2)-H functionalization: Protective group free route to coumestrol and 4′-O-methylcoumestrol
Naik, Mayuri M.,Kamat, Vijayendra P.,Tilve, Santosh G.
supporting information, p. 5528 - 5536 (2017/08/22)
A simple and efficient two step synthesis of coumestans is described. The key reaction in the synthesis is the use of easily available Cu(OAc)2 for C[sbnd]H functionalization of 3-(2-hydroxyphenyl)coumarin to give coumestan ring system via formal oxidative cyclization. This approach provided a short protective group free route to naturally occurring coumestrol and 4′-O-methylcoumestrol.
A NEW SYNTHESIS OF COUMESTAN: FORMAL SYNTHESIS OF COUMESTROL METHYL ETHER
Pandit, S. B.,Gadre, S. Y.
, p. 157 - 166 (2007/10/02)
A new route to synthesis of coumestan ring system has been developed and formal synthesis of methyl ether of coumestrol has been achieved.
