20503-09-7

Upstream product

• 13721-20-5 2-(3-chloro-4-methoxyphenyl)acetic acid 
• 103204-96-2 (2-hydroxy-4-methoxy-phenyl)-pyruvic acid 
• 552-41-0 1-(2-hydroxy-4-methoxyphenyl)ethanone 
• 89-84-9 2',4'-dihydroxy-4-acetophenone 
• 7569-58-6 2-(3-chloro-4-methoxyphenyl)acetonitrile 

Downstream Products

• 6496-89-5 2,4-dimethoxyphenylacetic acid 
• 76322-29-7 ethyl 2-(2-hydroxy-4-methoxyphenyl)acetate 
• 6600-61-9 3-(3,4-dimethoxy-benzylidene)-6-methoxy-3H-benzofuran-2-one 
• 673-22-3 2-Hydroxy-4-methoxybenzaldehyde 
• 212688-07-8 methyl (2-hydroxy-4-methoxyphenyl)acetate 
• 138330-22-0 7-methoxy-4-(4-methoxyphenyl)-2H-1-benzopyran 
• 328314-09-6 methyl (2-methoxycarbonylmethoxy-4-methoxyphenyl)acetate 
• 328314-19-8 4-benzyloxycarbonyl-7-methoxy-2H-1-benzopyran-3(4H)-one 
• 328314-31-4 7-methoxy-4-(2,4,6-trimethoxyphenyl)-2H-1-benzopyran-3(4H)-one 
• 328314-24-5 4-benzyloxycarbonyl-7-methoxy-4-(4-methoxyphenyl)-2H-1-benzopyran-3(4H)-one 
• 328314-25-6 4-benzyloxycarbonyl-7-methoxy-4-(2,4-dimethoxyphenyl)-2H-1-benzopyran-3(4H)-one 
• 328314-26-7 4-benzyloxycarbonyl-7-methoxy-4-(2,4,6-trimethoxyphenyl)-2H-1-benzopyran-3(4H)-one 
• 76322-24-2 7-methoxychroman-3-one 

Relevant academic research and scientific papers

Isoaurostatin: Total synthesis and structural revision

Isoaurostatin, a topoisomerase I inhibitor isolated from Thermomonospora alba has been synthesized for the first time from 2,4-dihydroxyacetophenone via 6-methoxybenzo-2(3H)-furanone in five steps. The E-isomer was converted into Z-isomer, but spectroscopic data of either of these two isomers did not match with those of the natural product. The structure of isoaurostatin has been revised to a known isoflavone, daidzein (2), based on careful analysis of spectroscopic data.

Design and synthesis of novel senkyunolide analogues as neuroprotective agents

A class of senkyunolide analogues bearing benzofuranone fragment were designed, synthesized and evaluated for their neuroprotective effect in models of oxygen glucose deprivation (OGD) and oxidative stress. All tested compounds showed neuroprotection profile based on the cell viability assay. In particular, derivatives 1f–1i possessing furoxan-based nitric oxide releasing functionality exhibited significant biological activities in OGD models. More importantly, compound 1g containing short linker with furoxan displayed the most potent neuroprotection at the concentration of 100 μM (cell survival up to 145.2%). Besides, 1g also showed the middle level neuroprotective effect in model of oxidative stress.

6-exo-trig Michael addition-lactonizations for catalytic enantioselective chromenone synthesis

The catalytic enantioselective 6-exo-trig Michael addition-lactonization of enone-acid substrates to form cis-chromenones with high diastereo- and enantiocontrol was developed using the commercially available isothiourea tetramisole. An acidic workup prov

A facile synthesis of phenylacetic acids via Willgerodt-Kindler reaction under PTC condition

Phenylacetic acids are efficiently synthesized from acetophenones via thiomorpholides under Phase Transfer Catalytic (PTC) condition. The reaction proceeds efficiently by using triethyl benzyl ammonium chloride (TEBA) as PTC and the reaction time decreased dramatically upto 1/5th (24-5) to afford pure products in good to excellent yield.