3172-99-4

Usage

Uses

Coumestrol dimethyl ether is a biochemical suitable for fluorescence.

InChI:InChI=1/C17H12O5/c1-19-9-3-5-11-13(7-9)21-16-12-6-4-10(20-2)8-14(12)22-17(18)15(11)16/h3-8H,1-2H3

Upstream product

• 61503-83-1 3-(2,4-dimethoxyphenyl)-4-hydroxy-7-methoxy-1-benzopyran-2-one 
• 39923-40-5 4-hydroxy-7-methoxy-3-(4-methoxyphenyl)-1-benzopyran-2-one 
• 673-22-3 2-Hydroxy-4-methoxybenzaldehyde 
• 20503-09-7 2-(2-hydroxy-4-methoxyphenyl)acetic acid 
• 60636-79-5 3-(2-hydroxy-4-methoxyphenyl)-7-methoxy-2H-chromen-2-one 
• 2210-75-5 1-(m-methoxy-phenoxy)-2,3-epoxy-propane 
• 1433-08-5 anhydrovariabilin 
• 1427216-07-6 3-((2-iodo-5-methoxyphenoxy)methyl)-6-methoxybenzofuran 
• 150-19-6 O-methylresorcine 
• 128980-54-1 C₁₇H₁₃IO₅ 
• 17575-15-4 4-hydroxy-7-methoxycoumarine 
• 151-10-0 1,3-Dimethoxybenzene 
• 299957-47-4 methyl 2-(2-methoxymethoxy-4-methoxybenzyloxy)-4-methoxy-phenylglyoxylate 
• 126809-68-5 2-(methoxymethoxy)-4-methoxybenzyl alcohol 

Downstream Products

• 479-13-0 coumestrol 
• 1433-08-5 anhydrovariabilin 

Relevant academic research and scientific papers

Method for preparing coumarino-heteroaromatic ring compounds and derivatives thereof through intramolecular cross-dehydrogenation coupling

The invention relates to a method for preparing coumarino-heteroaromatic ring compounds and derivatives thereof through intramolecular cross-dehydrogenation coupling. Specifically, compounds as shownin a formula Ia is subjected to intramolecular cross dehydrogenative coupling under the catalysis of palladium so as to prepare coumarin-heteroaromatic compounds as shown in a formula I, wherein groups in the formulas are as defined in the specification. The method is mild in reaction conditions, simple to operate, high in atom economy and applicable to a wide range of substrates, and high-yield preparation of multi-functionally substituted coumarin-heteroaromatic compounds and derivatives thereof is realized.

Copper-mediated synthesis of coumestans via C(sp2)-H functionalization: Protective group free route to coumestrol and 4′-O-methylcoumestrol

A simple and efficient two step synthesis of coumestans is described. The key reaction in the synthesis is the use of easily available Cu(OAc)2 for C[sbnd]H functionalization of 3-(2-hydroxyphenyl)coumarin to give coumestan ring system via formal oxidative cyclization. This approach provided a short protective group free route to naturally occurring coumestrol and 4′-O-methylcoumestrol.

Syntheses of pterocarpenes and coumestans via regioselective cyclodehydration

A highly efficient synthetic route to pterocarpenes and coumestans is described. BCl3-mediated dehydrative cyclization of 1,3-diaryloxyacetones under mild conditions permitted regioselective ring closure to afford 3-((2-iodoaryloxy)methyl)benzo

Synthesis of coumestan derivatives via FeCl3-mediated oxidative ring closure of 4-hydroxy coumarins

A concise and efficient approach to the syntheses of coumestan analogues has been developed. The underpinning strategy involves a FeCl 3-mediated direct intramolecular oxidative annellation of 4-hydroxy-3-phenyl-2H-chromen-2-one derivatives. Utilizing this synthetic protocol, a variety of coumestan derivatives were conveniently obtained from readily available reagents.

Hydrogen-atom abstraction/cyclization in synthesis. Direct syntheses of coumestan and coumestrol

The synthesis of coumestrol has been achieved in five steps from 1,3-dimethoxybenzene. The key step is a photochemical cyclization of a glyoxylate ester.

A new and efficient synthesis of coumestan and coumestrol

4-Aryloxy-3-iodocoumarins (4-aryloxy-3-iodo-2H-1-benzopyran-2-one), 4a-c, which are readily available by known procedures starting from 4-hydroxycoumarins 1 a,b and diacetoxyiodobenzenes 2a-c; are cyclized with palladium chloride in triethylamine to yield the coumestanes (6H-benzofuran[3,2-c][1]benzopyran-6-ones) 5a-c.

Isoflavonoids and the Other Consituents in Callus Tissues of Pueraria lobata

Puerarin, daidzin, daidzein, genistein, coumesterol, methyl 2,4-dihydroxybenzoate, a mixture of methyl p-hydroxybenzoate and methyl trans-p-hydroxycinnamate, phytosterols and aliphatic acid esters were isolated from the methanol extract of callus tissues, which were induced from the stem of Pueraria lobata OHWI.The main products at the final stage of callus culture were daidzin and puerarin in the suspension culture and daidzin in the static culture.The quantitative changes of daidzin, puerarin and daidzein during the growth of the callus tissues were investigated.Keywords---Pueraria lobata; Leguminosae; tissue culture; isoflavonoid; quantitative change