60645-32-1Relevant academic research and scientific papers
Neutral and zwitterionic polymorphs of 2-(p-tolylamino)nicotinic acid
Nath, Naba K.,Kumar, S. Sudalai,Nangia, Ashwini
, p. 4594 - 4605 (2011)
2-(p-Tolylamino)nicotinic acid (TNA) was crystallized in three polymorphic forms. The crystal structures of forms I and II are sustained by the neutral O-H???N hydrogen bond from the COOH donor to the pyridine N acceptor, whereas proton transfer occurred
Synthesis of 2-(arylamino)nicotinic acids in high-temperature water
Li, Zhenghua,Xiao, Shangyou,Liang, Ronghui,Xia, Zhining
, p. 1691 - 1697 (2012/10/29)
In hydrothermal reactions at 150-180 °C, 2-(arylamino)nicotinic acids were synthesized by amination of 2-chloronicotinic acid with aromatic amine derivatives, with potassium carbonate as base. The procedure is efficient, environmentally friendly, and practical, with moderate to excellent yields (up to 98%). Springer Science+Business Media B.V. 2012.
Catalyst-free amination of 2-chloronicotinic acid in water under microwave irradiation
Li, Zheng-Hua,Xia, Zhi-Ning,Chen, Gang
experimental part, p. 709 - 711 (2012/03/09)
A simple, efficient and environmental friendly method for the synthesis of 2-arylaminonicotinic acids derivatives by reacting 2-chloronicotinic acid with anilines with potassium carbonate as the base and water as the media under microwave irradiation is described. The synthesis of 2-arylaminonicotinic acids is important because they are nonsteroidal anti-inflammatory drugs.
Ring Transformation Reactions of 1-Substituted 2(1H)-Pyrimidinones and Related Compounds with Active Methylene Compounds
Katoh, Akira,Omote, Yoshimori,Kashima, Choji
, p. 2942 - 2946 (2007/10/02)
1-Substituted 2(1H)-pyrimidinones (I) underwent ring transformation with malononitrile and ethyl acetoacetate in the presence of sodium ethoxide to give 2-amino-3-pyridinecarbonitriles (II-VII) and N-(substituted)amino-3-pyridinecarboxylic acids (XIV and XV), respectively.Further, I reacted with ethyl cyanoacetate, dialkyl malonate, or ethyl benzoylacetate to give pyridine derivatives (VIII-XIII) bearing various functional groups at the C-3 position.The reaction of 1-substituted 2(1H)-pyrimidinethiones and 4,6-dimethyl-1-phenyl-2-phenylimino-1,2-dihydropyrimidine with active methylene compounds is also discussed.Keywords - ring transformation; 1-substituted 2(1H)-pyrimidinone; 1-substituted 2(1H)-pyrimidinethione; active methylene compound; sodium alkoxide; pyridine derivative.
