6066-84-8Relevant academic research and scientific papers
Unmasking Amides: Ruthenium-Catalyzed Protodecarbonylation of N-Substituted Phthalimide Derivatives
Yuan, Yu-Chao,Kamaraj, Raghu,Bruneau, Christian,Labasque, Thierry,Roisnel, Thierry,Gramage-Doria, Rafael
supporting information, p. 6404 - 6407 (2017/12/08)
The unprecedented transformation of a wide range of synthetically appealing phthalimides into amides in a single-step operation has been achieved in high yields and short reaction times using a ruthenium catalyst. Mechanistic studies revealed a unique, homogeneous pathway involving five-membered ring opening and CO2 release with water being the source of protons.
β-NITROGENATED RADICALS IN ORGANIC SYNTHESIS: REACTIONS WITH ELECTROPHILIC OLEFINS
Foubelo, Francisco,Lloret, Francisco,Yus, Miguel
, p. 260 - 266 (2007/10/03)
The reaction of iodoamide 1a or iodocarbamates 1b,c with electrophilic olefins 2a-e and in situ generated tributyltin hydride (from tributyltin chloride in a substoichiometric amout and an excess of sodium borohydride) in the presence of a catalytic amount of AIBN in dry ethanol at 0 to 20 deg C yields, after treatment with aqueous sodium fluoride, the expected coupling products 3aa-ce in moderate yields.Compounds 4a-c resulting from an iodine/hydrogen exchange in the starting materials 1a-c are also obtained as by-products in variable amounts.Parablas Clave: radicales β-funcionalizados, yodoamidas, formacion de enlaces C-C
