6068-80-0

Basic information

• Product Name: 347TRIMETHOXYQUERCETIN
• Synonyms: 347TRIMETHOXYQUERCETIN;quercetin 7,3',4'-trimethyl ether
• CAS NO: 6068-80-0
• Molecular Formula: C₁₈H₁₆O₇
• Molecular Weight: 344.31544
• Mol File: 6068-80-0.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 559.2°C at 760 mmHg
• Flash Point: 204.9°C
• Appearance: /
• Density: 1.407g/cm³
• Vapor Pressure: 2.42E-13mmHg at 25°C
• Refractive Index: 1.635
• CAS DataBase Reference: 347TRIMETHOXYQUERCETIN(CAS DataBase Reference)
• NIST Chemistry Reference: 347TRIMETHOXYQUERCETIN(6068-80-0)
• EPA Substance Registry System: 347TRIMETHOXYQUERCETIN(6068-80-0)

Safety Data

• Hazardous Substances Data: 6068-80-0(Hazardous Substances Data)

Usage

General Description

347TRIMETHOXYQUERCETIN is a chemical compound belonging to the flavonoid group, with three methoxy substituents on the quercetin molecule. It is commonly found in various plants and has been studied for its potential pharmacological properties, including antioxidant, anti-inflammatory, and anti-cancer effects. Its molecular structure and properties make it a promising candidate for the development of new pharmaceuticals and nutraceuticals. Additionally, 347TRIMETHOXYQUERCETIN has been reported to have potential therapeutic applications for various diseases, making it an exciting area of research for the pharmaceutical and medical industries.

InChI:InChI=1/C18H16O7/c1-22-10-7-11(19)15-14(8-10)25-18(17(21)16(15)20)9-4-5-12(23-2)13(6-9)24-3/h4-8,19,21H,1-3H3

Upstream product

• 520-33-2 hesperetin 
• 117-39-5 quercetol 
• 74-88-4 methyl iodide 
• 153-18-4 rutin 
• 24824-54-2 3,4-dimethoxybenzoic anhydride 
• 857617-58-4 2-benzoyloxy-1-(2,6-dihydroxy-4-methoxy-phenyl)-ethanone 

Downstream Products

• 7622-92-6 3,5-diacetoxy-2-(3,4-dimethoxy-phenyl)-7-methoxy-chromen-4-one 

Relevant articles and documents

Flavonoid compound as well as synthesis method and application thereof

The invention relates to a semi-synthetic flavonoid compound and an anti-inflammatory application thereof. The invention belongs to the technical field of medicines, particularly relates to synthesis of derivatives of natural products and an application of the derivatives in the anti-inflammatory aspect, and more particularly relates to a synthesis method of flavonoid compounds and an application of the flavonoid compounds in the anti-inflammatory aspect. According to the method, hesperetin is taken as a raw material, flavonol aglycone is synthesized, and finally flavonoid glycoside is synthesized through debenzylation and acetyl reaction. According to the invention, 32 flavonoid compounds, including 14 flavonoid aglycones and 18 flavonoid glycosides, including 15 known compounds and 17 unreported compounds, are synthesized in total. The part of the compounds show good in-vitro anti-inflammatory activity and can become anti-inflammatory drugs or lead compounds.

Biological evaluation and SAR analysis of O-methylated analogs of quercetin as inhibitors of cancer cell proliferation

Preclinical Research Using a high-throughout screening approach, the anticancer activities of 16 O-methylated (OMe) analogs of quercetin were assessed. The structure-activity relationships showed that OMe moieties at the 4′ and/or 7 positions were important for maintaining inhibitory activities against the 16 cancer cell lines. Furthermore, when the OH groups at the 3′ and 4′ positions were both replaced by OMe moieties, anticancer activity was enhanced.

Structural requirements of flavonoids and related compounds for aldose reductase inhibitory activity

The methanolic extracts of several natural medicines and medicinal foodstuffs were found to show an inhibitory effect on rat lens aldose reductase. In most cases, flavonoids were isolated as the active constituents by bioassay-guided separation, and among them, quercitrin (IC50=0.15 μM), guaijaverin (0.18 μM), and desmanthin-1 (0.082 μM) exhibited potent inhibitory activity. Desmanthin-1 showed the most potent activity, which was equivalent to that of a commercial synthetic aldose reductase inhibitor, epalrestat (0.072 μM). In order to clarify the structural requirements of flavonoids for aldose reductase inhibitory activity, various flavonoids and related compounds were examined. The results suggested the following structural requirements of flavonoid: 1) the flavones and flavonols having the 7-hydroxyl and/or catechol moiety at the B ring (the 3′,4′-dihydroxyl moiety) exhibit the strong activity; 2) the 5-hydroxyl moiety does not affect the activity; 3) the 3-hydroxyl and 7-O-glucosyl moieties reduce the activity; 4) the 2-3 double bond enhances the activity; 5) the flavones and flavonols having the catechol moiety at the B ring exhibit stronger activity than those having the pyrogallol moiety (the 3′,4′,5′-trihydroxyl moiety).