62861-51-2

Upstream product

• 1493-13-6 trifluorormethanesulfonic acid 
• 98-86-2 acetophenone 
• 536-74-3 phenylacetylene 
• 75-05-8 acetonitrile 
• 3282-32-4 2-diazo-acetophenone 
• 358-23-6 trifluoromethylsulfonic anhydride 
• 582-24-1 1-phenyl-2-hydroxyethanone 
• 13735-81-4 1-styrenyloxytrimethylsilane 
• 131170-47-3 oxy>iodo>benzene 
• 27607-77-8 trimethylsilyl trifluoromethanesulfonate 

Downstream Products

• 188817-19-8 2,4,4,4-tetrafluoro-1-phenylbutane-1,3-dione 
• 345579-91-1 (S)-5-[(R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxymethyl]-5-phenylimidazolidine-2,4-dione 
• 345578-66-7 (R)-4-[(R)-1-(3,5-Bis-trifluoromethyl-phenyl)-ethoxymethyl]-4-phenyl-imidazolidin-2-one 
• 874015-97-1 (R)-5-[(R)-1-(3,5-Bis-trifluoromethyl-phenyl)-ethoxymethyl]-5-phenyl-imidazolidine-2,4-dione 
• 606929-61-7 5-[(Benzyl-{3-[(R)-1-(3,5-bis-trifluoromethyl-phenyl)-ethoxymethyl]-3-phenyl-cyclobutyl}-amino)-methyl]-2,4-dihydro-[1,2,4]triazol-3-one 
• 606137-93-3 {3-[1-(3,5-bis-trifluoromethyl-phenyl)-ethoxymethyl]-1-methylcarbamoyl-3-phenyl-cyclobutyl}-carbamic acid tert-butyl ester 
• 606137-94-4 {3-[1-(3,5-bis-trifluoromethyl-phenyl)-ethoxymethyl]-1-dimethylcarbamoyl-3-phenyl-cyclobutyl}-carbamic acid tert-butyl ester 

Relevant academic research and scientific papers

FLUORINATED SULFONATE ESTERS OF ARYL KETONES FOR NON-IONIC PHOTO-ACID GENERATORS

Non-ionic photo-acid generating (PAG) compounds were prepared that contain an aryl ketone group having a perfluorinated substituent alpha to the ketone carbonyl. The non-polymeric PAGs release a sulfonic acid when exposed to high energy radiation such as deep UV or extreme UV light. The photo-generated sulfonic acid has a low diffusion rate in an exposed resist layer subjected to a post-exposure bake (PEB) at 100° C. to 150° C., resulting in formation of good line patterns after development. At higher temperatures, the PAGs can also undergo a thermal reaction to form a sulfonic acid. The perfluorinated substituent provides improved thermal stability and hydrolytic/nucleophilic stability.

NON-IONIC LOW DIFFUSING PHOTO-ACID GENERATORS

Non-ionic photo-acid generating (PAG) compounds were prepared that contain an aryl ketone group. The disclosed non-polymeric PAGs release a strong sulfonic acid when exposed to high energy radiation such as deep UV or extreme UV light. The photo-generated sulfonic acid has a low diffusion rate in an exposed resist layer subjected to a post-exposure bake (PEB) at 100° C. to 150° C., resulting in formation of good line patterns after development. At higher temperatures, the PAGs undergo a thermal reaction to form a sulfonic acid.

Metal-free [2 + 2 + 1] annulation of alkynes, nitriles, and oxygen atoms: Iodine(III)-mediated synthesis of highly substituted oxazoles

The metal-free [2 + 2 + 1] annulation of alkynes, nitriles, and O-atoms for the regioselective assembly of 2,4-disubstituted and 2,4,5-trisubstituted oxazole compounds has been achieved by the use of PhIO with TfOH or Tf 2NH. The present reaction could be applied to a facile synthesis of an anti-inflammatory drug.

Nucleophilic fluorination of triflates by tetrabutylammonium bifluoride

(Chemical Equation Presented) Careful examination of nucleophilicity, basicity, and leaving group ability led us to discover the nucleophilic fluorination of triflates by weakly basic tetrabutylammonium bifluoride, which provides excellent yields with minimal formation of elimination-derived side products. Primary hydroxyl groups as well as secondary hydroxyl groups in acyclic chains or in five-membered rings are excellent substrates, whereas benzylic and aldol-type secondary hydroxyl groups give poor yields as a result of the instability of their triflates.

Cyclic urea derivatives as potent NK1 selective antagonists. Part II: Effects of fluoro and benzylic methyl substitutions

A series of novel five-membered urea derivatives as potent NK1 receptor antagonists is described. The effects of substitution of a 4-fluoro group at the phenyl ring and the introduction of an α-methyl group at the benzylic position to improve p

Cyclobutane derivatives as potent NK1 selective antagonists

A series of novel cyclobutane derivatives as potent and selective NK1 receptor antagonists is described. Several compounds in this series exhibited high in vitro binding affinity (Ki {less-than or slanted equal to} 1 nM), and potent

A Novel Efficient Synthesis of α-Keto Triflates

The direct and efficient synthesis of α-keto triflates by the reaction of aromatic ketones with thallium(III) triflate is decribed.

Synthesis and biological evaluation of the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: Identification of 4-[5-(4-methylphenyl)- 3(trifluoromethyl)-1h-pyrazol-1-yl]benzenesulfonamide (sc-58635, celecoxib)

A series of sulfonamide-containing 1,5-diarylpyrazole derivatives were prepared and evaluated for their ability to block cyclooxygenase-2 (COX-2) in vitro and in vivo. Extensive structure-activity relationship (SAR) work was carried out within this series, and a number of potent and selective inhibitors of COX-2 were identified. Since an early structural lead (1f, SC- 236) exhibited an unacceptably long plasma half-life, a number of pyrazole analogs containing potential metabolic sites were evaluated further in vivo in an effort to identify compounds with acceptable pharmacokinetic profiles. This work led to the identification of 1i (4-[5-(4-methylphenyl)-3- (trifluoromethyl)-1H-pyrazol-1-y1]benzenesulfonamide, SC-58635, celecoxib), which is currently in phase III clinical trials for the treatment of rheumatoid arthritis and osteoarthritis.

A general approach to unsymmetrical tricoordinate iodinanes: Single step preparation of mixed iodosobenzene sulfonates Phl(X)OSO2R, via reaction of iodosobenzene with Me3SiX

Mixed iodonium sulfonates of the type Phl(X)OSO2R (X = OAc, NHAc, NCO, CN; R = CF3, C4F9, p-CH3C6H4) have been prepared by the reaction of PhlO with the appropriate derivatives of trimethylsilane.

HYPERVALENT IODINE OXIDATION OF TRIMETHYLSILYL ENOL ETHERS OF KETONES: A DIRECT SYNTHESIS OF α-KETO TRIFLATES

α-Trifluroromethanesulfonoxy ketones (α-keto triflates) have been synthesized under very mild conditions by the reaction of silyl ethers of ketones and trimethylsilyl trifluoromethanesulfonate/iodosobenzene in dichloromethane.