606935-04-0Relevant articles and documents
Enantiomeric resolution of fluorous mixture by chiral CD columns: Asymmetric reduction of a mixture of fluorous ketones
Nakamura, Yutaka,Takeuchi, Seiji,Okumura, Kazuo,Ohgo, Yoshiaki,Matsuzawa, Hiroshi,Mikami, Koichi
, p. 6221 - 6225 (2007/10/03)
Asymmetric reduction of a mixture of four fluorous ketone analogues was carried out with (R)-oxazaborolidine as a catalyst. The fluorous mixture products were resolved by a reverse phase HPLC with chiral β-cyclodextrin column to result in good separation of the enantiomers.
Copper catalyzed Grignard cross-coupling reaction with β-perfluoroalkyl-substituted alkyl halides
Shimizu, Rie,Yoneda, Eiichi,Fuchikami, Takamasa
, p. 5557 - 5560 (2007/10/03)
Coupling reaction of β-perfluoroalkyl-substituted alkyl halides with Grignard reagents such as phenyl-, vinyl-, allyl-, benzyl-, and alkyl-magnesium halides was catalyzed by copper salts or complexes to give the corresponding cross-coupling products in good yields. α,ω-Diiodoalkane bearing a polyfluoroalkylene moiety also reacted with 2 equiv. of Grignard reagent in the presence of copper catalyst to given α,ω-bi-functionalized product.
