606975-63-7Relevant academic research and scientific papers
Syntheses of β-D-Galf-(1→6)-β-D-Galf-(1→5)-D-Galf and β-D-Galf-(1→5)-β-D-Galf-(1→6)-D-Galf, trisaccharide units in the galactan of Mycobacterium tuberculosis
Gandolfi-Donadio, Lucia,Gallo-Rodriguez, Carola,De Lederkremer, Rosa M.
, p. 6928 - 6934 (2003)
The galactofuran is a crucial constituent of the cell wall of mycobacteria. An efficient synthesis of the two trisaccharide units of the galactan is described. The strategy relies on the use of substituted D-galactono-1,4-lactones as precursors for the internal and the reducing galactofuranoses. Dec-9-enyl β-D-Galf-(1→6)-β-D-Galf-(1→ 5)-β-D-Galf (2) and dec-9-enyl β-D-Galf-(1→5)-β -D-Galf-(1→6)-β-D Galf (9) so far reported as convenient substrates for the galactofuranosyl transferase, and possibly useful for immunological studies, were obtained by the trichloroacetimidate method of glycosylation.
