105-48-6Relevant articles and documents
Synthesis and characterization of task-specific ionic liquids possessing two Broensted acid sites
Liu, Dan,Gui, Jianzhou,Zhu, Xiangqin,Song, Lijuan,Sun, Zhaolin
, p. 759 - 765 (2007)
Task-specific ionic liquids possessing two Broensted acid sites with -COOH, HSO-4, or H2PO-4 groups have been designed, synthesized, and characterized. Under mild conditions and without any additional organic solvent, the esterification of isopropanol by chloroacetic acid could be carried out in these new task-specific ionic liquids. In comparison with most of acidic ionic liquids in current use, these ionic liquids are halogen free and more environmentally benign as media and catalysts. Copyright Taylor & Francis Group, LLC.
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Morin,Bearse
, p. 1596,1598 (1951)
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New Diesters Derived from Piperine: In silico Study and Evaluation of Their Antimicrobial Potential
Barbosa-Filho, José M.,Brand?o, Maria Cláudia R.,Lima, Edeltrudes O.,Lira, Bruno F.,Neto, Hermes D.,Souza, Helivaldo D. S.,Trindade, Emmely O.,de Athayde-Filho, Petr?nio F.
, p. 1668 - 1678 (2020/10/09)
Piperine, previously extracted from black pepper (Piper nigrum L.), was used as a precursor for the synthesis of twelve new diester derivatives. The final products were obtained through the bimolecular nucleophilic substitution reaction (SN2) of the alkyl 2-chloroacetates and the salt of piperic acid, obtained from the basic hydrolysis of piperine. The compounds were synthesized with yields of 55-84% and characterized by infrared spectroscopy and 1H and 13C nuclear magnetic resonance. The evaluation of the compounds’ potential as new drug candidates was done through an in silico study of ADME properties (absorption, distribution, metabolization and excretion) and evaluation of antimicrobial activity against bacterial strains (Staphylococcus aureus and Pseudomonas aeruginosa), yeasts (Candida albicans and Candida tropicalis) and filamentous fungi (Aspergillus fumigatus, Aspergillus flavus and Aspergillus niger). The in silico study showed that the compounds were good drug candidates and antimicrobial evaluation demonstrated that 9 of the 12 compounds exhibited a minimum inhibitory concentration (MIC) ranging 1024-256 μg mL?1
A pure Radix Salviae Miltiorrhizae usually different propyl ester synthesis method (by machine translation)
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Paragraph 0052; 0058-0059, (2018/04/02)
The invention relates to a pure Radix Salviae Miltiorrhizae usually different propyl ester synthesis method, the method comprising the protocatechuic aldehyde as a starting raw material, after phenmethyl protection phenol hydroxy, Darzens ring oxidation, and then through the arrowhead class catalyst/hydrogen or Raney nickel/hydrogen catalytic reduction, to obtain pure Radix Salviae Miltiorrhizae usually different propyl ester. The method of the invention the synthetic product purity can be up to 98%, a yield of 55%. And the synthesis method of the invention, and is simple, short route, the productive rate is high, and is suitable for large-scale industrial production. (by machine translation)