60708-65-8 Usage
Uses
Used in Pharmaceutical Synthesis:
(2Z)-3-(4-bromophenyl)-2-imino-1,3-thiazolidin-4-one is used as a key intermediate in the synthesis of pharmaceuticals for its ability to contribute to the development of new drugs with potential therapeutic applications.
Used in Agrochemical Development:
In the agrochemical industry, (2Z)-3-(4-bromophenyl)-2-imino-1,3-thiazolidin-4-one is utilized as a component in the creation of agrochemicals, leveraging its chemical properties to enhance crop protection and management.
Used in Drug Discovery:
(2Z)-3-(4-bromophenyl)-2-imino-1,3-thiazolidin-4-one is employed as a potential candidate in drug discovery due to the biological activities of its thiazolidin-4-one moiety, which includes anti-inflammatory, antioxidant, and antimicrobial properties.
Used for Enhancing Hydrophobic Interactions:
The bromophenyl group in (2Z)-3-(4-bromophenyl)-2-imino-1,3-thiazolidin-4-one allows for hydrophobic interactions, which is beneficial in the design of drugs that require specific pharmacokinetic properties, thus it is used to improve the solubility and absorption of drug molecules.
Check Digit Verification of cas no
The CAS Registry Mumber 60708-65-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,0,7,0 and 8 respectively; the second part has 2 digits, 6 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 60708-65:
(7*6)+(6*0)+(5*7)+(4*0)+(3*8)+(2*6)+(1*5)=118
118 % 10 = 8
So 60708-65-8 is a valid CAS Registry Number.
60708-65-8Relevant academic research and scientific papers
Design and development of novel Mycobacterium tuberculosis l-alanine dehydrogenase inhibitors
Saxena, Shalini,Samala, Ganesh,Sridevi, Jonnalagadda Padma,Devi, Parthiban Brindha,Yogeeswari, Perumal,Sriram, Dharmarajan
, p. 401 - 414 (2015/03/04)
In the present study, we used crystal structure of MTB L-AlaDH protein complex with N6-methyl adenosine for structure based virtual screening of in house database to identify new small molecule inhibitors for MTB-L-AlaDH. Two molecules identified as better leads and were modified synthetically to obtain thirty novel analogues belonging to 2-iminothiazolidine-4-ones and 4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxamides. Among the screened compounds four (4n, 4o, 12 and 14) emerged as potent inhibitors displaying IC50 values ranging from 0.58 ± 0.02 to 1.74 ± 0.03 μM against MTB-L-AlaDH and were non-cytotoxic at 50 μM. Some of these synthesized compounds also exhibited good activity against nutrient starved dormant MTB cells. The most potent inhibitors were found to stabilize the protein which was confirmed biophysically through differential scanning fluorimetry.
