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CAS

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6072-04-4

N-tosyllysine methyl ester is a chemical compound with the molecular formula C15H22N2O4S. It is a derivative of lysine, an essential amino acid, where the amino group is protected by a tosyl group (tosyl = 4-methylbenzenesulfonyl), and the carboxylic acid group is esterified with a methyl group. N-tosyllysine methyl ester is commonly used in peptide synthesis as a protected amino acid building block, allowing for the formation of peptide bonds while preventing unwanted side reactions. The tosyl group can be removed under mild conditions, and the methyl ester can be hydrolyzed to regenerate the free carboxylic acid, making N-tosyllysine methyl ester a valuable tool in the synthesis of complex peptide sequences.

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  • 6072-04-4 Structure

  • Basic information

    1. Product Name: N-tosyllysine methyl ester
    2. Synonyms: N-tosyllysine methyl ester
    3. CAS NO:6072-04-4
    4. Molecular Formula: C14H22N2O4S
    5. Molecular Weight: 0
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 6072-04-4.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 462.8°C at 760 mmHg
    3. Flash Point: 233.7°C
    4. Appearance: /
    5. Density: 1.195g/cm3
    6. Vapor Pressure: 9.62E-09mmHg at 25°C
    7. Refractive Index: 1.534
    8. Storage Temp.: N/A
    9. Solubility: N/A
    10. CAS DataBase Reference: N-tosyllysine methyl ester(CAS DataBase Reference)
    11. NIST Chemistry Reference: N-tosyllysine methyl ester(6072-04-4)
    12. EPA Substance Registry System: N-tosyllysine methyl ester(6072-04-4)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 6072-04-4(Hazardous Substances Data)

6072-04-4 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 6072-04-4 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,0,7 and 2 respectively; the second part has 2 digits, 0 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 6072-04:
(6*6)+(5*0)+(4*7)+(3*2)+(2*0)+(1*4)=74
74 % 10 = 4
So 6072-04-4 is a valid CAS Registry Number.
InChI:InChI=1/C14H22N2O4S/c1-11-6-8-12(9-7-11)21(18,19)16-13(14(17)20-2)5-3-4-10-15/h6-9,13,16H,3-5,10,15H2,1-2H3/t13-/m0/s1

6072-04-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name TLME

1.2 Other means of identification

Product number -
Other names N2-(toluene-4-sulfonyl)-L-lysine methyl ester

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:6072-04-4 SDS

6072-04-4Relevant articles and documents

Nitrile Synthesis by Aerobic Oxidation of Primary Amines and in situ Generated Imines from Aldehydes and Ammonium Salt with Grubbs Catalyst

Utsumi, Tatsuki,Noda, Kenta,Kawauchi, Daichi,Ueda, Hirofumi,Tokuyama, Hidetoshi

supporting information, p. 3583 - 3588 (2020/08/05)

Herein, a Grubbs-catalyzed route for the synthesis of nitriles via the aerobic oxidation of primary amines is reported. This reaction accommodates a variety of substrates, including simple primary amines, sterically hindered β,β-disubstituted amines, allylamine, benzylamines, and α-amino esters. Reaction compatibility with various functionalities is also noted, particularly with alkenes, alkynes, halogens, esters, silyl ethers, and free hydroxyl groups. The nitriles were also synthesized via the oxidation of imines generated from aldehydes and NH4OAc in situ. (Figure presented.).

Novel aminopeptidase N inhibitors with improved antitumor activities

Wang, Qiang,Shi, Qiao,Huang, Lu

, p. 98 - 106 (2015/11/17)

A series of aminopeptidase N (APN) inhibitors were designed and synthesized. Enzyme inhibitory, docking and antiproliferative studies were performed to evaluate the derived molecules. Molecule D15, with IC50 values of 10.9 μM, showed the best performance in the APN enzymatic inhibition assay. The binding pattern of molecule D9 and D15 in the active site of APN was predicted by docking studies. Hydrophobic and H-bond interactions were discovered to make key roles in the ligand-receptor bindings. Compared with the previous C7, several molecules such as D9, D14 and D15, exhibited significantly improved activities in inhibiting the growth of HL-60, ES-2, A549 and PLC cell lines.

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