60736-96-1

Usage

Uses

Used in Medicinal Chemistry:
1-(4-fluorobenzyl)pyrrolidin-2-one is used as a compound with potential pharmacological properties for the development of medications that may provide relief from pain (analgesic), induce a calming effect (sedative), or reduce anxiety (anxiolytic).
Used in Drug Development:
In the pharmaceutical industry, 1-(4-fluorobenzyl)pyrrolidin-2-one is used as a starting material or intermediate in the synthesis of more complex molecules with therapeutic applications.
Used in Organic Synthesis:
1-(4-fluorobenzyl)pyrrolidin-2-one is used as a building block in organic synthesis to create a variety of complex molecules for different applications across various industries, including the development of new materials and chemicals.

Upstream product

• 616-45-5 2-pyrrolidinon 
• 459-46-1 4-Fluorobenzyl bromide 
• 20825-71-2 2(3H)-furanone 
• 140-75-0 para-fluorobenzylamine 
• 459-57-4 4-fluorobenzaldehyde 
• 56-12-2 4-amino-n-butyric acid 

Downstream Products

• 60736-97-2 (E)-1-(4-fluorobenzyl)-2-(nitromethylene)pyrrolidine 

Relevant academic research and scientific papers

Frankfurt shift, II: Further contributions on the intramolecular shift of N-oxides of tertiary cycloalkylamines to lactams (Frankfurt shift)

The basis knowledge of the Frankfurt shift could be extended by experiments on the kinetic isotopic effect, an experiment with incubation in 18O2-atmosphere and a shift with 1-(4-fluorobenzyl)-piperidine-N-oxide (4). Furthermore the shift was established in a whole animal experiment (rat).

Synthesis of Lactams by Reductive Amination of Carbonyl Derivatives with ω-Amino Fatty Acids under Hydrosilylation Conditions

An efficient method for the preparation of lactams from ω-amino fatty acids under hydrosilylation is described. A variety of lactams such as pyrrolidinones, piperidinones and 2-azepanones were selectively synthesised in moderate to excellent yields (29 examples, up to 95 % isolated yields) with a good functional group tolerance. Notably, no metallic based catalyst was required to perform this transformation.

Vasoactive agents

A vasoactive drug is provided which comprises a compound having GPR14-antagonizing activity or salts thereof.

USE OF POLYPEPTIDE

The present invention provides uses of a polypeptide having a ligand activity to a sensory epithelium neuropeptide-like receptor (SENR) which is a G protein-coupled receptor protein, and a DNA encoding the same. More specifically, the present invention provides an anti-attention-deficit-disorder or anti-narcolepsy agent, which comprises a polypeptide having a ligand activity for SENR or a salt thereof, as well as a method for screening compounds having an anti-attention-deficit-disorder or anti-narcolepsy activity or compounds having an anti-anxiety, anti-depression, anti-insomnia, anti-schizophrenia or anti-fear activity or salts thereof, which comprises using the above polypeptide or a precursor protein of the polypeptide or a salt thereof.

2-Methoxy-benzamide derivatives

The invention provides novel 2-methoxy-benzamide derivatives of the formula: STR1 WHEREIN, M IS AN INTEGER FROM 2 TO 5; A is a linear or branched alkylene chain of 1 to 4 carbon atoms; R2 is chlorine, SO2 R5 or SO2 NR6 R7 ; R3 is hydrogen or alkyl of 1 to 4 carbon atoms; R5 is alkyl of 1 to 4 carbon atoms; EACH OF R6 and R7 is independently hydrogen or alkyl of 1 to 4 carbon atoms in the form of racemates or optical isomers and their pharmaceutically acceptable acid addition salts which are useful in the treatment of psychosomatic and psychotic disturbances.

2-Methoxy-benzamide derivatives

The invention provides novel 2-methoxy-benzamide derivatives of the formula: STR1 in which n is 1 or 2; R1 represents a cycloalkyl-alkyl radical of formula: (CH2)m -CH-A- , a phenylalkyl radical of formula STR2 (in which m