607373-84-2

Usage

Uses

Used in Pharmaceutical Industry:
2,4-Dimethoxy-5-nitropyridine serves as a crucial intermediate in the synthesis of pharmaceuticals, contributing to the development of new medications and therapeutic agents. Its chemical properties make it a versatile building block in the creation of diverse drug molecules.
Used in Agrochemical Industry:
In the agrochemical sector, 2,4-Dimethoxy-5-nitropyridine is utilized as an intermediate for the production of various agrochemicals, including pesticides and herbicides. Its involvement in these syntheses helps to enhance crop protection and yield.
Used in Dye and Pigment Manufacturing:
2,4-Dimethoxy-5-nitropyridine is also employed in the manufacturing of dyes and pigments, where its chemical structure imparts color and stability to these products. This application is vital in industries such as textiles, plastics, and printing inks.
Used in Organic Compounds Synthesis:
Beyond its direct applications, 2,4-Dimethoxy-5-nitropyridine is a valuable intermediate for synthesizing a range of other organic compounds, expanding its utility across multiple chemical and industrial processes.

InChI:InChI=1S/C7H8N2O4/c1-12-6-3-7(13-2)8-4-5(6)9(10)11/h3-4H,1-2H3

Upstream product

• 607373-82-0 2-hydroxy-4-methoxy-5-nitro pyridine 
• 124-41-4 sodium methylate 
• 31872-62-5 4-methoxy-3-nitro-pyridine 

Downstream Products

• 89943-34-0 4,6-bis(methyloxy)-3-pyridinamine 
• 925213-65-6 [1-ethyl-6-(methyloxy)-1H-imidazo[4,5-c]pyridin-2-yl]acetonitrile 

Relevant academic research and scientific papers

Discovery of aminofurazan-azabenzimidazoles as inhibitors of rho-kinase with high kinase selectivity and antihypertensive activity

The discovery, proposed binding mode, and optimization of a novel class of Rho-kinase inhibitors are presented. Appropriate substitution on the 6-position of the azabenzimidazole core provided subnanomolar enzyme potency in vitro while dramatically improving selectivity over a panel of other kinases. Pharmacokinetic data was obtained for the most potent and selective examples and one (6n) has been shown to lower blood pressure in a rat model of hypertension. Despite many available treatments, hypertension remains a prevalent problem. In fact, some 30% of hypertensive patients are unable to reach their blood pressure goals. Thus, a new anti-hypertensive treatment, which acts on a broader patient population, would be an important addition to existing treatments. A number of vasoconstrictive agents, including angiotensin II, endothelin-1, and urotensin-II, exert their effect through RhoA and the downstream kinase Rho-kinase (ROCK1).1 Because of its central role in the control of smooth muscle contraction, inhibition of ROCK1 could lead to a more broadly efficacious anti-hypertensive agent.2 ROCK1 inhibitors have been shown to relax vascular smooth muscle and lower blood pressure in several animal models of hypertension.3 Therefore, we began an effort to identify potent ROCK1 inhibitors with pharmacokinetic profiles consistent with once daily oral dosing.