60750-24-5

Basic information

• Product Name: BENZYL 1,6-DIMETHYL-2-OXO-4-PHENYL-1,2,3,4-TETRAHYDROPYRIMIDINE-5-CARBOXYLATE
• Synonyms: TOSLAB 739912;BENZYL 1,6-DIMETHYL-2-OXO-4-PHENYL-1,2,3,4-TETRAHYDROPYRIMIDINE-5-CARBOXYLATE
• CAS NO: 60750-24-5
• Molecular Formula: C₂₀H₂₀N₂O₃
• Molecular Weight: 336.38
• Mol File: 60750-24-5.mol
• Article Data: 1

Chemical Properties

• Melting Point: 119-120 °C
• Boiling Point: 542.9±50.0 °C(Predicted)
• Appearance: /
• Density: 1.193±0.06 g/cm3(Predicted)
• PKA: 11.09±0.70(Predicted)
• CAS DataBase Reference: BENZYL 1,6-DIMETHYL-2-OXO-4-PHENYL-1,2,3,4-TETRAHYDROPYRIMIDINE-5-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: BENZYL 1,6-DIMETHYL-2-OXO-4-PHENYL-1,2,3,4-TETRAHYDROPYRIMIDINE-5-CARBOXYLATE(60750-24-5)
• EPA Substance Registry System: BENZYL 1,6-DIMETHYL-2-OXO-4-PHENYL-1,2,3,4-TETRAHYDROPYRIMIDINE-5-CARBOXYLATE(60750-24-5)

Safety Data

• Hazardous Substances Data: 60750-24-5(Hazardous Substances Data)

Upstream product

• 5396-89-4 benzyl acetoacetate 
• 100-52-7 benzaldehyde 
• 598-50-5 N-Methylurea 

Downstream Products

• 60750-38-1 1,2,3,4-tetrahydro-1,6-dimethyl-2-oxo-4-phenylpyrimidine-5-carboxylic acid 
• 143335-38-0 1,2,3,4-tetrahydro-1,3,6-trimethyl-2-oxo-4-phenyl-5-pyrimidinecarboxylic acid 
• 95928-47-5 Furfuryl Ester of 1,6-Dimethyl-4-phenyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic Acid 
• 143317-18-4 1,2,3,4-tetrahydro-1,3,6-trimethyl-2-oxo-4-phenyl-5-pyrimidinecarboxylic acid benzyl ester 

Relevant articles and documents

Microwave-assisted solution phase synthesis of dihydropyrimidine C5 amides and esters

Multifunctionalized dihydropyrimidine-5-carboxylic amides and esters are generated in a multistep sequence integrating a variety of enabling and high throughput technologies such as automated or parallel microwave synthesis, the use of polymer-supported reagents, fluorous synthesis and purification strategies, and a continuous flow hydrogenation system. The key dihydropyrimidine-5-carboxylic acid intermediates are obtained in two steps by Biginelli multicomponent condensation of benzyl or allyl β-ketoesters with aldehydes and urea/thioureas, followed by suitable benzyl or allyl deprotection strategies. Further functionalization of the acid cores with amines using polymer-supported coupling reagents or with alcohols utilizing Mitsunobu chemistry provides the desired amides or esters, respectively.